Disclosed herein are cells including pluripotent stem cells that conditionally express an immunosuppressive factor and related methods of their use and generation. In some embodiments, the cells disclosed do not express MHC I and MHC II human leukocyte antigens, and in some cases, also do not express one or more TCR complexes. In some embodiments, hypoimmunogenicity of the cells is controlled by activation of a controllable expression system upon contacting the cells with a specific factor or agent.

Disclosed herein are cells including pluripotent stem cells that conditionally express an immunosuppressive factor and related methods of their use and generation. In some embodiments, the cells disclosed do not express MHC I and MHC II human leukocyte antigens, and in some cases, also do not express one or more TCR complexes. In some embodiments, hypoimmunogenicity of the cells is controlled by activation of a controllable expression system upon contacting the cells with a specific factor or agent.

The present invention relates to a composition for intrapericardial injection comprising stem cells, and a use thereof, and more particularly, to a composition for improving the therapeutic effect of stem cells by effective transplantation of the stem cells into the pericardium.

The present invention relates to a composition for intrapericardial injection comprising stem cells, and a use thereof, and more particularly, to a composition for improving the therapeutic effect of stem cells by effective transplantation of the stem cells into the pericardium.

This disclosure relates to hydrogel compositions with isolated mitochondria suspended therein. The compositions are for providing protection to injured tissue, as well as tissue proximal to a site of injury. The hydrogel provides structural support while the mitochondria are able to prevent or slow cellular death. In some aspects, the compositions include N-acetylcysteine amide and/or acetyl-L-carnitine.

This disclosure relates to hydrogel compositions with isolated mitochondria suspended therein. The compositions are for providing protection to injured tissue, as well as tissue proximal to a site of injury. The hydrogel provides structural support while the mitochondria are able to prevent or slow cellular death. In some aspects, the compositions include N-acetylcysteine amide and/or acetyl-L-carnitine.

Compositions and methods are provided for induction and maintenance of quiescence of stem cells.

Compositions and methods are provided for induction and maintenance of quiescence of stem cells.

The present invention discloses an application of TREM2.sup.hi macrophages in preparation of drugs for treating cardiac dysfunction, and belongs to the technical field of medicine. The present invention discloses for the first time that there is a kind of macrophage subsets for high expression of a triggering receptor expressed on myeloid cells-2 in cardiac derived macrophages, which has a strong function of recognizing and reducing mitochondrial damage and plays an important role in maintaining a cardiac metabolic balance. Therefore, the TREM2.sup.hi macrophages have important application value in treatment of the cardiac dysfunction.

The present invention relates to methods for obtaining skeletal muscle derived cells (SMDC), and the use of SMDCs in a method of preventing and/or treating neuromyopathies and/or myopathies, wherein the neuromyopathy and/or myopathy is incontinence, in particular a urinary and/or an anal or fecal incontinence.