This invention relates generally to compositions and methods for treatment of pancreatic cancer. The present invention relates more particularly to use of JNK inhibition together with administration of TRAIL to selectively suppress cancer stem cells.

Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in Crohn's Disease.

Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in Crohn's Disease.

Embodiments of the disclosure encompass methods and compositions related to the ability of RNA to enhance therapeutic activity of fibroblasts. In some embodiments, administration of double stranded RNA is performed through providing polyinosinicpolycytidylic acid (poly (I:C)) or a derivative thereof at a concentration sufficient to induce therapeutic properties and/or to augment therapeutic properties onto said fibroblasts. In one embodiment, enhanced therapeutic activity comprises augmentation of fibroblast migratory activity; efficacy for angiogenesis; efficacy for immune modulation; differentiation ability; production of one or more trophic factors; and/or the ability to resist apoptosis.

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet.

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet.

An enriched amnion derived tissue graft has a stromal matrix layer and an epithelium layer. A stromal matrix layer may contain a basement membrane layer, a compact layer, a fibroblast layer, and an intermediate layer. An amnion derived tissue graft may have a plurality of tissue layers and the layers may be configured with the epithelium layers toward the inside and the stromal matrix layers toward the outside surface. An enriched portion may be coated onto or be configured within a tissue layer and have an increased concentration of cells, of proteins, growth factors, seed cells, pharmaceuticals or any combination thereof. A carrier fluid such as amniotic fluid may be used to produce an enrichment composition for coating the tissue graft. The cells within the enriched portion may be stem cells from the amnion, or cells from other tissue and may be seed cells selected based on the treatment location.

An enriched amnion derived tissue graft has a stromal matrix layer and an epithelium layer. A stromal matrix layer may contain a basement membrane layer, a compact layer, a fibroblast layer, and an intermediate layer. An amnion derived tissue graft may have a plurality of tissue layers and the layers may be configured with the epithelium layers toward the inside and the stromal matrix layers toward the outside surface. An enriched portion may be coated onto or be configured within a tissue layer and have an increased concentration of cells, of proteins, growth factors, seed cells, pharmaceuticals or any combination thereof. A carrier fluid such as amniotic fluid may be used to produce an enrichment composition for coating the tissue graft. The cells within the enriched portion may be stem cells from the amnion, or cells from other tissue and may be seed cells selected based on the treatment location.

A medicine developed for treatment of psoriasis and production method thereof are disclosed. This medicine for treatment of psoriasis developed in the scope of the present invention comprises tallow, larch resin, beeswax, gum mastic, propolis, Alkanna tinctoria, alum and Juniper tar. The production method of the psoriasis medicine of the present invention includes the steps of: Melting the tallow at 300° C. by continuously mixing it with the beeswax, adding first the gum mastica and then the propolis to the obtained molten mixture, adding ground larch resin to the mixture together with alum, finally adding ground Alkanna tinctoria and juniper tar to the mixture, obtaining a homogenous mixture by means of continuous mixing, filtering the homogenous mixture, obtaining the medicine for treatment of psoriasis, which is the final product in the form an elute.

A medicine developed for treatment of psoriasis and production method thereof are disclosed. This medicine for treatment of psoriasis developed in the scope of the present invention comprises tallow, larch resin, beeswax, gum mastic, propolis, Alkanna tinctoria, alum and Juniper tar. The production method of the psoriasis medicine of the present invention includes the steps of: Melting the tallow at 300° C. by continuously mixing it with the beeswax, adding first the gum mastica and then the propolis to the obtained molten mixture, adding ground larch resin to the mixture together with alum, finally adding ground Alkanna tinctoria and juniper tar to the mixture, obtaining a homogenous mixture by means of continuous mixing, filtering the homogenous mixture, obtaining the medicine for treatment of psoriasis, which is the final product in the form an elute.