The present invention discloses a substance for treating and/or preventing allergic diseases and a design method and preparation method thereof. The stable structure corresponding to the substance related to the allergic disease is used as the substance for treating and/or preventing the allergic disease. The essence of disease is the imbalance of biological structure system. The imbalance of the structure of the substance in the biological structure system will cause diseases related to said substance. The present disclosure relates to the treatment and/or prevention of the allergic disease by recognizing the stable structure corresponding to the substance by the body, adjusting the expression of its gene expression or genes by the self-adaptation, self-organization and other functions of body's structural system, and restoring the balance of the structure of the substance in the biological structure system.

The present invention relates to the discovery that different stem cell types (e.g., bone marrow-derived mesenchymal stem cells (RM-MSC) and adipose-derived mesenchymal stem cells (AT-MSC)) undergo large changes in lung epithelial marker 5 expression depending on the substrate on which they are cultured. The present invention includes methods and compositions for differentiating of mesenchymal stem cells, such as bone marrow and adipose tissue mesenchymal stem cells, into lung cells, populations of lung cells, and methods of alleviating or treating a lung defect in a subject in need thereof.

The present invention relates to the discovery that different stem cell types (e.g., bone marrow-derived mesenchymal stem cells (RM-MSC) and adipose-derived mesenchymal stem cells (AT-MSC)) undergo large changes in lung epithelial marker 5 expression depending on the substrate on which they are cultured. The present invention includes methods and compositions for differentiating of mesenchymal stem cells, such as bone marrow and adipose tissue mesenchymal stem cells, into lung cells, populations of lung cells, and methods of alleviating or treating a lung defect in a subject in need thereof.

Tissue prostheses having a base structure and a physiological sensor system. The tissue prostheses are adapted and configured to induce remodeling of damaged tissue and regeneration of new tissue and concurrently detect and monitor physiological characteristics when implanted in the subject.

Provided is a method of designing and preparing a substance for treating and/or preventing a tumor, wherein, a stable structure corresponding to a tumor-related substance is used as the substance for treating and/or preventing the tumor. The essence of disease is the imbalance of organism structural system. The imbalance of the structure of substance in the organism structure system will cause diseases related to the substance. Disclosed is a method that the organism regulates genes or the expression of genes, restores the balance of the structures of substances in the organism structural system, and treats and/or prevents a disease related to the tumor, through the self-adaptation and self-organization of the structure system of the organism after recognizing the stable structure corresponding to the substance.

Provided is a method of designing and preparing a substance for treating and/or preventing a tumor, wherein, a stable structure corresponding to a tumor-related substance is used as the substance for treating and/or preventing the tumor. The essence of disease is the imbalance of organism structural system. The imbalance of the structure of substance in the organism structure system will cause diseases related to the substance. Disclosed is a method that the organism regulates genes or the expression of genes, restores the balance of the structures of substances in the organism structural system, and treats and/or prevents a disease related to the tumor, through the self-adaptation and self-organization of the structure system of the organism after recognizing the stable structure corresponding to the substance.

A method for extracting animal-derived pulmonary surfactants, including forming an extract of an animal lung, forming a precipitate by mixing the extract of the animal lung with a cationic flocculant solution containing poly(diallyldimethyl ammonium chloride) (pDADMAC), separating an organic phase containing pulmonary surfactants from the precipitate, recovering the pulmonary surfactants from the organic phase.

A method for extracting animal-derived pulmonary surfactants, including forming an extract of an animal lung, forming a precipitate by mixing the extract of the animal lung with a cationic flocculant solution containing poly(diallyldimethyl ammonium chloride) (pDADMAC), separating an organic phase containing pulmonary surfactants from the precipitate, recovering the pulmonary surfactants from the organic phase.

The present disclosure provides a substance for treatment and/or prevention of diseases, the method for designing the substance, and the method for preparing the substance. A stable structure corresponding to a substance is used as the substance for treatment and/or prevention of diseases associated with the substance. The essence of disease is the imbalance of the biological structure system. Different structural imbalances will cause different diseases. The present invention discloses that the biological body recognizes the stable structure corresponding to the substance, adjusts its gene or gene expression by the self-adaptation and self-organization functions of its own structural system, and restores the biological structure system to be related to the substance. The balance of structure, treatment and/or prevention of diseases related to the substance.

Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial in the art and at present, methods for isolating and using adult lung stem cells from humans lack reproducibility. Thus, the methods and compositions described herein are advantageous over the present state of knowledge in the art and permit the generation of human lung progenitor cells for treatment, tissue engineering, and screening assays.