The present application relates to probiotic confection-based compositions comprising lactic acid-producing bacteria and oil-based compositions comprising the same.

The present application relates to probiotic confection-based compositions comprising lactic acid-producing bacteria and oil-based compositions comprising the same.

Methods of protecting skin from damage due to cold thermal stress are disclosed. The methods include topically applying a composition that includes an Artemia salina extract from rehydrated Artemia salina cysts to skin at risk of damage from thermal stress, particularly from cold thermal stress or repeated temperature variations. The composition includes a physiologically acceptable medium for delivery of the Artemia salina extract.

Methods of protecting skin from damage due to cold thermal stress are disclosed. The methods include topically applying a composition that includes an Artemia salina extract from rehydrated Artemia salina cysts to skin at risk of damage from thermal stress, particularly from cold thermal stress or repeated temperature variations. The composition includes a physiologically acceptable medium for delivery of the Artemia salina extract.

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO.sub.2 or CO.sub.2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO.sub.2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO.sub.2 or CO.sub.2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO.sub.2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

The present invention is related to methods of making crustacean oil compositions. In particular, the crustacean oil compositions are krill oil compositions. In some embodiments, the krill oil compositions are concentrated in phospholipids. These concentrated phospholipid krill oil compositions have a sufficient flowability to permit successful encapsulation at phospholipid concentrations that is currently unattainable in the art. Such phospholipid krill oil compositions are capable of encapsulation even though they may have a phospholipid concentration ranging between approximately 60%-99% and a viscosity ranging between 100,000-3,000,000 cP. Such concentrated phospholipid krill oil compositions may be created using a small molecule organic solvent/water extraction mixture and/or sub-critical or super-critical fluid extraction at low temperatures followed by a drying process to remove water and organic solvent (e.g., for example, ethanol).

The present invention is related to methods of making crustacean oil compositions. In particular, the crustacean oil compositions are krill oil compositions. In some embodiments, the krill oil compositions are concentrated in phospholipids. These concentrated phospholipid krill oil compositions have a sufficient flowability to permit successful encapsulation at phospholipid concentrations that is currently unattainable in the art. Such phospholipid krill oil compositions are capable of encapsulation even though they may have a phospholipid concentration ranging between approximately 60%-99% and a viscosity ranging between 100,000-3,000,000 cP. Such concentrated phospholipid krill oil compositions may be created using a small molecule organic solvent/water extraction mixture and/or sub-critical or super-critical fluid extraction at low temperatures followed by a drying process to remove water and organic solvent (e.g., for example, ethanol).

A dietary supplement composition is formulated in a therapeutic amount to treat and alleviate symptoms of joint pain in an animal such as a human patient or non-human animal. The dietary supplement composition comprises hyaluronic acid/hyaluronan, which includes pro-inflammatory low molecular weight sodium hyaluronate fragments having a molecular weight of 0.5 to 300 kilodaltons (kDa) in an oral dosage form. The hyaluronic acid/hyaluronan also includes hyaluronic acid/hyaluronan having a molecular weight greater than the 0.5 to 300 kDa range. The composition may include eggshell membrane.

A dietary supplement composition is formulated in a therapeutic amount to treat and alleviate symptoms of joint pain in an animal such as a human patient or non-human animal. The dietary supplement composition comprises hyaluronic acid/hyaluronan, which includes pro-inflammatory low molecular weight sodium hyaluronate fragments having a molecular weight of 0.5 to 300 kilodaltons (kDa) in an oral dosage form. The hyaluronic acid/hyaluronan also includes hyaluronic acid/hyaluronan having a molecular weight greater than the 0.5 to 300 kDa range. The composition may include eggshell membrane.