The present invention discloses a crystal form, a preparation method and an application of a 4′-substituted nucleoside compound I having the following structure, including salts, prodrugs, and compositions thereof. Animal pharmacokinetic studies demonstrated that the effective drug concentrations of Compound Ia and Compound Ig in HIV target cells, peripheral blood mononuclear cells (PBMC), were effective in inhibiting HIV replication after 7 and 5 days, respectively. Therefore, Compound I can be used as a long-acting drug for preventing and treating AIDS. R is selected from ethynyl, azide, and cyano groups, X is selected from hydrogen and fluorine, and B is selected from B1 and B2.

The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and/or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.

A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.

The present disclosure relates, in part, to a composition for promoting virolysis and/or inhibition of infection of a vims in a mammal, the composition comprising a lectin mutant. In certain embodiments, the lectin mutant comprises mutant cyanovirin N (CVN) and mutant Griffithsin (GRFT). The present disclosure further provides methods of treating, preventing, and/or ameliorating viral infection in a subject. In certain embodiments, the viral infection is caused by a vims selected from the group consisting of SARS-CoV-1, SARS-CoV-2, and HIV-I. The present disclosure further provides cyclic compounds useful for the treatment, prevention, and/or amelioration of HIV-I in a subject.--

Novel nucleic acid sequences, vectors and adenoviral genomes are provided herein. Corresponding novel adenoviruses and genotypes and compositions are also provided. The novel nucleic acid sequences, vectors, genomes, adenoviruses, genotypes and compositions are useful in therapy. The novel nucleic acid sequences, vectors, genomes, adenoviruses, genotypes and compositions are particularly useful in treating or preventing cancer.

The present disclosure relates to compositions comprising albuvirtide, an HIV-1 fusion inhibitor, including liquid compositions and stable lyophilized compositions. The present disclosure also provides the manufacturing process thereof and use of the these compositions for the prevention, treatment or prophylaxis of diseases caused by HIV.

Provided are a pharmaceutical composition for treatment of a tumor or cancer, and an application thereof. The pharmaceutical composition comprises an oncolytic rhabdovirus and a small molecule CD38 inhibitor such as rhein that are administered via direct local injection or systemic administration or intratumoral delivery. The oncolytic rhabdovirus has the characteristic of recognizing tumor cells and would not cause damage to normal cells. Meanwhile, the small molecule CD38 inhibitor has the activity of specifically inhibiting T-cell receptor molecules. The combined use of the oncolytic rhabdovirus and the small molecule CD38 inhibitor has significant advantages in safety and efficacy.

Provided are a pharmaceutical composition for treatment of a tumor or cancer, and an application thereof. The pharmaceutical composition comprises an oncolytic rhabdovirus and a small molecule CD38 inhibitor such as rhein that are administered via direct local injection or systemic administration or intratumoral delivery. The oncolytic rhabdovirus has the characteristic of recognizing tumor cells and would not cause damage to normal cells. Meanwhile, the small molecule CD38 inhibitor has the activity of specifically inhibiting T-cell receptor molecules. The combined use of the oncolytic rhabdovirus and the small molecule CD38 inhibitor has significant advantages in safety and efficacy.

The present invention relates to a combination of a picornaviridae capsid binding anti-viral agent and at least one further anti-viral agent for use in a method for treatment of a picornavirales infection in a mammalian subject comprising administering said combination to said mammalian subject. It further relates to an anti-viral agent for use in a method for 5 treatment of a picornavirales infection in a mammalian subject comprising administering said anti-viral agent to said mammalian subject, wherein the picornavirales infection is caused by a virus causing in vivo-expression of a VP1-protein detectable in infected tissue through immunohistochemical staining using an antibody raised against the VP1-protein of Ljungan virus, while said virus is not detectable in said infected tissue using a PCR assay 10 adapted for detection of Ljungan virus, as well as a pharmaceutical composition comprising Ljungan virus VP1 protein and a pharmaceutically acceptable adjuvant.

Embodiments of the present disclosure pertain to methods of treating or preventing Alzheimer's disease or symptoms of Alzheimer's disease in a subject by administering to the subject an active agent that includes an adenovirus-36 E4orf1 protein, a nucleic acid encoding an adenovirus-36 E4orfl protein, or combinations thereof. Additional embodiments of the present disclosure pertain to the active agents of the present disclosure for use in the treatment or prevention of Alzheimer's disease or symptoms of Alzheimer's disease.