The present invention discloses dry formulations of room temperature stable vaccines that comprise a live attenuated virus, a sugar stabilizer, and an amino acid stabilizer. The present invention also discloses the manufacture of such vaccines and methods of protecting an animal by administration of such vaccines.

The present invention provides a fusion protein comprising an HPV cancer-causing protein segment, a coding sequence thereof and an application thereof in preparing drugs for detecting or treating HPV-related diseases. The fusion protein can simultaneously induce the humoral immunity and the cellular immunity for a high-risk HPV cancer protein and has anti-cancer activity in vivo.

Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

Capsular saccharides derived from serogroups W135 and Y of Neisseria meningitidis have altered levels of O-acetylation at the 7 and 9 positions of their sialic acid residues, and can be used to make immunogenic compositions. Relative to unmodified native saccharides, derivatives of the invention are preferentially selected during conjugation to carrier proteins, and conjugates of the derivatives show improved immunogenicity compared to native polysaccharides.

Capsular saccharides derived from serogroups W135 and Y of Neisseria meningitidis have altered levels of O-acetylation at the 7 and 9 positions of their sialic acid residues, and can be used to make immunogenic compositions. Relative to unmodified native saccharides, derivatives of the invention are preferentially selected during conjugation to carrier proteins, and conjugates of the derivatives show improved immunogenicity compared to native polysaccharides.

The invention relates to a bonding and forming device for an inner box of a paper box and surface paper. The bonding and forming device comprises a stand, a lifting platform, a paper box inner support member, a flanging pressing plate, an ejector pin, a left hairbrush, a right hairbrush, a first pushing part, a front hairbrush, a rear hairbrush and a second pushing part and also comprises a driving device, a first control device a second control device, a third control device, a fourth control device and a fifth control device, wherein the driving device is used for driving the ejector pin to rise or fall; the first control device is used for controlling the paper box inner support member to rise or fall; the second control device is used for controlling the left hairbrush and the right hairbrush to stretch; the third control device is used for controlling the first pushing part to stretch; the fourth control device is used for controlling the front hairbrush and the rear hairbrush to stretch; the fifth control device is used for controlling the second pushing part to stretch; an inhibiting device is arranged between the first control device and the driving device; and the paper box inner support member and the flanging pressing plate are respectively provided with a through hole for the ejector pin to pass through. By adopting the technical scheme, according to the bonding and forming device for the inner box of the paper box and the surface paper, provided by the invention, the inner box and other surfaces of the surface paper can be automatically bonded to be formed after a bottom plate of the inner box and the bottom surface of the surface paper are bonded. The degree of automation is high and the production efficiency is high.

The invention relates to a bonding and forming device for an inner box of a paper box and surface paper. The bonding and forming device comprises a stand, a lifting platform, a paper box inner support member, a flanging pressing plate, an ejector pin, a left hairbrush, a right hairbrush, a first pushing part, a front hairbrush, a rear hairbrush and a second pushing part and also comprises a driving device, a first control device a second control device, a third control device, a fourth control device and a fifth control device, wherein the driving device is used for driving the ejector pin to rise or fall; the first control device is used for controlling the paper box inner support member to rise or fall; the second control device is used for controlling the left hairbrush and the right hairbrush to stretch; the third control device is used for controlling the first pushing part to stretch; the fourth control device is used for controlling the front hairbrush and the rear hairbrush to stretch; the fifth control device is used for controlling the second pushing part to stretch; an inhibiting device is arranged between the first control device and the driving device; and the paper box inner support member and the flanging pressing plate are respectively provided with a through hole for the ejector pin to pass through. By adopting the technical scheme, according to the bonding and forming device for the inner box of the paper box and the surface paper, provided by the invention, the inner box and other surfaces of the surface paper can be automatically bonded to be formed after a bottom plate of the inner box and the bottom surface of the surface paper are bonded. The degree of automation is high and the production efficiency is high.

A composition for treating or preventing COVID-19 infection is described. The composition includes attenuated Measles virus particles; attenuated Mumps virus particles; attenuated Rubella II virus particles; scorpion antivenom; and a pharmaceutically acceptable carrier. The composition can be used in a method of treating COVID-19 infection in a subject, and can also be used in a method of vaccinating a subject to decrease the risk or severity of infection by COVID-19.

The present invention regards a new and Improved HVT-vectored ND-IBD vaccine, comprising a recombinant HVT comprising the VP2 gene from IBDV and the F gene from NDV to a target animal. The recombinant HVT can be used in a vaccine for poultry, which displayed good viral vector replication, effective expression of the NDV F—and IBDV VP2 genes, improved immunoprotection against ND and IBD, and improved genetic stability over prior art constructs.