There is provided a method of sensitising a eukaryotic cell to ultrasound stimulation, said method comprising increasing the mechano-sensitivity of a transmembrane ion channel of the cell to ultrasound by introducing a plurality of entire exogenous gas vesicles proximal to the surface of the cell.

The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

An acoustic wave medical treatment of a body part of an individual in which nanoparticles are administered to the body part of the individual and the acoustic wave is applied on the body part. The acoustic wave is sequentially applied on the body part, and/or the nanoparticles are magnetosomes. Also, compositions that include these nanoparticles.

The present invention relates to a sensitizer-peptide conjugate for use in the treatment of cancer. In particular, the present invention relates to a sensitizer-peptide conjugate for use in the treatment of melanoma. The use of such sensitizer-peptide conjugate in photodynamic therapy or sonodynamic therapy is also disclosed. According to the present invention, there is provided a sensitizer-peptide conjugate for use in the treatment of cancer; wherein the sensitizer-peptide conjugate comprises at least one sensitizer and at least one peptide.

An acoustic wave medical treatment of a body part of an individual in which nanoparticles are administered to the body part of the individual and the acoustic wave is applied on the body part. The acoustic wave is sequentially applied on the body part, and/or the nanoparticles are magnetosomes. Also, compositions that include these nanoparticles.

The present invention includes system, methods, and compositions for the generation of novel oxygen microbubbles, and in particular oxygen microbubbles with a longer acyl-chain phospholipid for increased circulation persistence and oxygen payload. The novel oxygen microbubbles of the invention may be particularly suited for the treatment of tumor hypoxia in radiation oncology.

The present disclosure is directed to devices for, and method of, priming the tumor microenvironment with pressure pulses to enhance the efficacy of anticancer therapeutic agents, in a subject in need thereof. Further, increased response of solid tumors locally exposed to stress waves to systemically administered therapeutic agents, is disclosed. The pressure-pulse tumor-priming device comprises: a pulsed laser system (1), a light guide (2) to direct laser pulses to one or more light-to-pressure transducers (3), the one or more light-to-pressure transducers absorbing laser pulses from the pulsed laser system and generating pressure pulses, a tumor-positioning support structure (4) configured to couple one or more light-to-pressure transducers with a solid tumor (5), and a control system (6) to limit the exposure of the solid tumor to the pressure pulses. Anticancer therapeutic agents may be administered before, after or during the priming of solid tumors with pressure pulses.

The present invention relates to an immune checkpoint inhibitor conjugated with an sonosensitizer, a use thereof, and the like. The immune checkpoint inhibitor conjugate conjugated with an sonosensitizer according to the present invention has selectivity for tumors with respect to targeted therapy and specifically responds to ultrasonic waves, and thus can be used to produce drugs for diagnosing and treating cancer. Particularly, the conjugate of the present invention exhibits excellent solubility and stability in an aqueous solution, and provides excellent anticancer effects as compared with simple immune checkpoint inhibitors, and therefore, is expected to be useful as a novel drug for treating cancer.

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as drugs, may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate as compounds such as a protoporphyrin compound in tumor cells. After such accumulation, such compounds are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

Provided herein are compositions, such as, for example, CXCL 10-secreting antigen presenting cells, and methods for ultrasound-induced blood-brain bander disruption (e.g., low-intensity pulsed ultrasound (LIPU)) to treat a brain cancer in a mammalian subject.