Multifunctional compositions and methods are provided for therapeutic treatment of bacteria and cancers and for fluorescence diagnosis. Systems generate in situ reactive oxygen species such as singlet oxygen (.sup.1O.sub.2), hydroxyl radical (OH) and Juglone, and other chemotherapeutic agents. Methods provided selectively produce greater amounts of one reactive oxygen species over others. Variations are effective in aerobic, anaerobic or H.sub.2O.sub.2 rich environments and in presence of, or absence of, light. In H.sub.2O.sub.2 rich environment in absence of light, variations decompose H.sub.2O.sub.2 into O.sub.2 gas to remove excess H.sub.2O.sub.2 for elimination of hypoxic environment. Variations are formed of porphyrins, naphthalene derivatives, and metal ions, for illustration, free base tetrakis Ar substituted porphyrine core without metal or halide substitution but having hydroxyphenyl and alkyl pyridyl substituents at meso positions combined with dihydroxynaphthalene and +3 hydrated metal ions.

The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO<->, COS<->, SO3<->, PO3<2->, COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.

Compounds including a tetrapyrrolic or reduced tetrapyrrolic group/moiety and an epidermal growth factor receptor targeting group are disclosed. For example, a compound includes a tetrapyrrolic or reduced tetrapyrrolic group or moiety, a linker moiety, an epidermal growth factor receptor targeting group, and, optionally, a PET-active functional group. Uses of the compounds, for example, methods of treating a hyperproliferative tissue in an individual, and kits including one or more of the compounds are also provided.

The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

Disclosed is a conjugated polymer-based nanoprobe, including a fluorescent conjugated polymer, a surface ligand, a target molecule, a near-infrared fluorescent dye and optionally a gadolinium-containing magnetic resonance contrast agent. This application also discloses a method for preparing the conjugated polymer-based nanoprobe, including: adding raw materials to an organic solvent followed by ultrasonication to obtain a mixture; and adding the mixture to ultrapure water and continuously ultrasonicating the reaction mixture. The conjugated polymer-based nanoprobe can be applied in a combined molecular imaging technique of near infrared fluorescence imaging, photoacoustic imaging and magnetic resonance imaging to effectively recognize metastatic lymph nodes and normal lymph nodes, and it can be retained in the metastatic lymph nodes for a long time, meeting the requirements for long-term observation. Moreover, the near-infrared fluorescent conjugated polymer-based nanoprobe can generate reactive oxygen under irradiation, which is suitable for the photodynamic treatment of tumors.

The present invention relates to a medicinal material for light therapy, comprising a matrix material and a photosensitizer, wherein the photosensitizer is dispersed inside the matrix material by copolymerization, is mixed inside the matrix material, or attached to the surface of the matrix material by surface grafting, modification, coating and the like. The present material can kill diseased tissue cells with a radiation under selected wavelength so as to obtain a phototherapy treatment of ophthalmic diseases. The present invention also provides a process for preparing the material and a use in preparing an ophthalmic medical device.

Provided herein are porphyrinato-lanthanide complexes useful as theranostic agents and methods of preparation and use thereof. The porphyrinato-lanthanide complexes are useful in the treatment and imaging of cancer.

A platinum complex includes a structure of Formula (I). A method for treating a subject suffering from cancer includes a step of administering an effective amount of the platinum complex to the subject. A method for inhibiting the growth of cancer cells includes the step of contacting a population of cancer cells with an effective amount of the platinum complex. The platinum complexes are particularly suitable for treatment of cancer through, in particular, photodynamic therapy.

An aspect relates to a cancer-specific polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. The polypeptide according to an aspect may bind specifically to LGR5 protein expressed in a tumor tissue, and when binding to a labeling material (for example, a fluorescent material), a cancer that expresses the LGR5 protein may be diagnosed. Furthermore, when the polypeptide binds to an isotope, a metastatic tumor may be also diagnosed. When the polypeptide according to an aspect binds to a photosensitizer and is then administered to a subject, the photosensitizer may be activated through light irradiation so that cancer cells may be killed, thereby enabling the prevention, amelioration, or treatment of cancer.

The present disclosure provides nerve targeting peptides, including those comprising the amino acid sequence of any one of SEQ ID NOS: 1-710; conjugates comprising such nerve targeting peptides and a cargo molecule; compositions comprising said peptides and conjugates; and methods of said peptides and conjugates in surgical procedures and other applications.