A method comprises providing a plurality of nanostructures comprising a base material. The plurality of nanostructures are exposed to a first material at a first deposition temperature. The plurality of nanoparticles are exposed to a second material at a second deposition temperature, and exposed to a Boron-10 (.sup.10B) containing material at a third deposition temperature so as to form a .sup.10B-metal oxide based composite nanostructure.

The present invention relates to compositions and methods for imaging and treating various diseases and disorders, including cancers. The composition of the invention can include a plurality of biodegradable micro-beads, each embedding a plurality of nano-beads, further including a polymer, a radionuclide, a radionuclide chelator, a radioligand, a chemotherapeutic agent, and a cell-penetrating peptide. Upon injection into a blood vessel supplying a cancer tumor, the micro-beads lodge into the tumor and degrade, releasing the nano-beads with a therapeutic or diagnostic agent. The compositions and methods of the invention provide a more homogeneous and deeper distribution of radiation or chemotherapeutic agents throughout the target tumor. The micro-beads provide a local, sustained, and controlled delivery nano-beads including therapeutic or diagnostic agents.

The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.

Boron Enriched Linker (BEL) compositions and methods of making BELs are disclosed herein. Consequently, the BELs can be conjugated to antibodies or antibody fragments to create Antibody Boron Conjugates (ABCs) to provide a method of treating cancer, immunological disorders and other disease by utilizing a Neutron Capture Therapy modality.

A neutron capture therapy system includes a therapy table on which an irradiation target is placed, a neutron beam irradiation unit which irradiates the irradiation target placed on the therapy table with a neutron beam, a position measurement unit which measures a position of the irradiation target placed on the therapy table, and a radiation dose distribution output unit which outputs a radiation dose distribution of a neutron beam used for irradiating the irradiation target, based on an amount of positional misalignment of the position of the irradiation target measured by the position measurement unit.

A measurement device includes a sensing portion and a measuring portion. The sensing portion contains at least a fluorescent material whose emitting of fluorescent light ceases due to an action of a radioactive beam. The measuring portion measures a radiation quantity of the radioactive beam, with which the sensing portion is irradiated, based on an amount of decrease in the intensity of the fluorescent light emitted by the fluorescent material contained in the sensing portion when the radioactive beam acts on at least a portion of the fluorescent material. The fluorescent light is emitted due to irradiation of the fluorescent material by an excitation source.

A neutron capture therapy system that irradiates an object to be irradiated with a neutron beam by using an irradiation device, and includes a treatment planning device, a control device, and the irradiation device included in a network via which transmission and reception of information are possible, in which the treatment planning device creates treatment plan information related to a treatment plan and transmits the treatment plan information to the control device, in which the control device adjusts the treatment plan information transmitted from the treatment planning device to be usable in the irradiation device, and in which the irradiation device irradiates the object to be irradiated with the neutron beam on the basis of the treatment plan information adjusted by the control device.

The present disclosure discloses a boron neutron capture therapy system comprising: a boron neutron capture therapy device and an -amino acid-like boron trifluoride compound having a structure shown as formula (I) below:

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Wherein: R is selected from hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, hydroxymethyl, 1-hydroxyethyl, benzyl or hydroxybenzyl; M is H or metal atom. The energy generated from the action of the neutron beam generated by the boron neutron capture therapy device on the -amino acid-like boron trifluoride compound destroys tumor cell DNA. In another aspect, the present disclosure discloses a use of an -amino acid-like boron trifluoride compound in the preparation of a medicament for tumor therapy.

Borylated Amino Acid compositions comprising tyrosine derivatives BTS and BTS(OMe) and novel methods of making BTS and BTS(OMe) are disclosed herein. Consequently, the BTS and/or BTS(OMe) can be scaled up to commercial scale and administered to patients as a Neutron Capture Agent and provide a method of treating cancer, immunological disorders, and other disease by utilizing a Neutron Capture Therapy modality.

An irradiation method and system for irradiating a target volume, the method comprising: providing thermal neutron absorbing nuclides (such as in the form of a high neutron cross-section agent) at the target volume; and producing neutrons by irradiating nuclei in or adjacent to the target volume with a beam of particles consisting of any one or more of protons, deuterons, tritons and heavy ions, thereby prompting production of the neutrons through non-elastic collisions between the atoms in the path of the beam (including the target) and the particles. The neutron absorbing nuclides absorb neutrons produced in the non-elastic collisions, thereby producing capture products or fragments that irradiate the target volume.