A system and method is disclosed for non-contact detection and/or imaging and/or monitoring target subsurface tissue of at least one of human or animal anatomy. The system applies a first optical excitation signal to an outer tissue surface at a first location on the anatomy, which excites the target subsurface tissue to produce acoustic signals which are transmitted to an outer tissue surface of the anatomy. A gel-like, impedance matching and signal converting (IMASC) material layer is applied to the outer tissue surface at a second location on the anatomy. The IMASC material layer contains material elements which are able to influence characteristics of an optical signal impinging and reflected from the IMASC material, in accordance with acoustic signals that have been reflected from the target subsurface tissue, and which propagate into the IMASC material. An optical ultrasound detection system is used to process the reflected optical signals reflected from the IMASC material to provide information that may be used to provide an image of the target subsurface tissue.

The present disclosure relates to ratiometric detection compositions comprising a reference dye and a sensor dye that are PEGylated dyes, and microneedles comprising said compositions. The present disclosure further relates to methods of ratiometric detection/measurement/monitoring of analytes in a subject using the ratiometric detection compositions of the present disclosure.

The present invention provides novel antigens of an allergy to soybean, methods and kits for diagnosing an allergy to soybean, pharmaceutical compositions comprising such an antigen, soybeans or processed products of soybean in which such an antigen is eliminated, and a tester for determining the presence or absence of a soybean antigen in an object of interest.

Provided are a novel Dermatophagoides farinae protein, and a diagnostic drug, a prophylactic drug and a therapeutic drug for an allergic disease caused by Dermatophagoides farinae. A Dermatophagoides farinae protein selected from the group consisting of the following (a) to (c), or a fragment peptide thereof: (a) a protein including an amino acid sequence set forth in SEQ ID NO:2; (b) a protein including an amino acid sequence in which one or several amino acids have been substituted, deleted, or added relative to the amino acid sequence set forth in SEQ ID NO:2, and having allergenicity of Dermatophagoides farinae; and (c) a protein including an amino acid sequence having 90% or higher identity with the amino acid sequence set forth in SEQ ID NO:2, and having allergenicity of Dermatophagoides farinae.

A method for administering tests using a regional antigen testing kit is provided. The method comprises providing the regional antigen testing kit, extracting a predetermined amount of concentrated antigen from one of a plurality of concentrated antigens, dispensing the predetermined amount of concentrated antigen into a corresponding one of a plurality of wells, as indicated by visual indicia, repeating the extracting and dispensing steps until a desired number of the plurality of wells contain concentrated antigen, providing a prick tester having a plurality of needles extending thereon, aligning the plurality of needles of the prick tester with the plurality of wells, inserting each of the plurality of needles of the prick tester into one of the plurality of wells, and applying the plurality of needles of the prick tester to the skin of a patient to elicit a potential response.

Described herein is a protection factor evaluation system for determining a protection factor of a skin protection agent with a radiation source with exactly one LED, a detector unit with exactly one photodiode, a control unit and an evaluation unit. Furthermore, the invention relates to a method for determining a sun protection factor of a skin protection agent with the method steps of emitting radiation from precisely one LED of a radiation source, detecting remitted radiation with precisely one photodiode of a detector unit and evaluating the protection factor in an evaluation wavelength range, wherein the protection factor of the protection agent is evaluated from the radiation and a transmission spectrum, and wherein the data of the transmission spectrum for determining the protection factor are in silico and/or in vitro data.

A method of selecting a surfactant system suitable for infants and young children is disclosed.

A method of selecting a skin barrier system suitable for infants and young children is disclosed.

Disclosed herein is a formulation that can take the form of an emulsion which contains total enteral or parenteral nutrition for a recipient subject. The formulation includes as the sole fat components: (i) medium chain triglycerides; and (ii) very long chain fatty acids selected from (a) very long chain omega-3 polyunsaturated fatty acids; and (b) docosahexaenoic acid and arachidonic acid in a ratio of about 10:1 (v/v or w/w) to about 2000:1 (v/v or w/w). The sole fat components provide about 10% to about 90% total calories of the formulation, and the medium chain triglycerides provide about 25%-95% total fat calories of the formulation. Methods and kits for utilizing the formulation and for treating various disorders and diseases that involve an inflammatory response are also disclosed.

The present invention discloses the use of Mycobacterium tuberculosis antigens for use in in vivodetermination of the presence of Mtbinfection in immunocompromised persons or persons co-infected with HIVand the for preparing a diagnostic reagent for skin testing (a skin test reagent) for robust assessment of the presence of Mtbinfection in an individual wherein the individual is an immunocompromised person or a person co-infected with HIV.