The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.

The present invention provides a silicon-based polymer contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising silicon-based polymer oil emulsified in water. Exemplary silicon-based polymer oil has a viscosity between about 50 cSt and 100,000 cSt. In various embodiments, the silicon-based polymer oil is emulsified with a vehicle or dispersing medium compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable vehicle in which the material is emulsified in the presence of a surfactant. In an exemplary embodiment, the silicon-based polymer comprises 30% or more of the weight of the contrast material formulation. The invention also provides methods for imaging of the abdomen by dual energy CT or spectral CT contemporaneously with the delivery of the silicon-based polymer contrast material into the bowel lumen and the delivery of a second complementary contrast material into the blood vessels or other body compartments. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues to generate multiple resultant CT images with the contrast medium of the invention subtracted or highlighted.

A radio-opaque composition is formulated to enable a clinician to apply custom markings to a surface, such as a patient's skin or a surgical drape on the patient. More specifically, the radio-opaque composition may be used to write on the surface. The markings may be well-defined and contrast with the surface to which they are applied. Such a composition may include a liquid radio-opaque component that includes one or more radio-opaque materials that have been dissolved in a solvent, as well as a solid radio-opaque component with particles of one or more radio-opaque materials dispersed throughout a carrier, such as the solvent of the liquid radio-opaque component. Marking apparatuses that may be used to write with the radio-opaque composition are also disclosed, as are methods for using the radio-opaque composition.

A capsule for measuring motility of a target area is provided. An article of manufacture for measuring motility of a target area, comprises a first capsule and a second capsule. The a first capsule comprises a first capsule enclosure; a first identification marker, having a weight of W.sub.m1, wherein the first identification marker comprises a first visible element under X-ray, substantially circular shaped and having an outer diameter of A. The second capsule comprises a second capsule enclosure; a second identification marker, having a weight of W.sub.m2, wherein the second identification marker comprises a second visible element under X-ray, substantially circular shaped and having an outer diameter of B. The first capsule enclosure and second capsule enclosure are substantially identical under all measurements in digestive behaviors; the weight of the first identification marker W.sub.m1 and the weight of the second identification marker W.sub.m2 differs less than 0.01 g; A is less than B.

The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.

Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer, at least one flexomer, and at least one visualization agent. Methods of making and using these polymers are also described.

The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovascolature within a patient, among many other uses.

The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in site, including the use of the same for embolizing vasculature including the neurovasculature within a patient among many other uses.

The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.

The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.