The present invention relates to a formulation of a therapeutic or diagnostic agent in the form of a nano-emulsion, to its preparation method and to the use of this formulation for treating or diagnosing hormone-dependent cancers or cancers of organs synthesizing steroidal hormones.

The disclosure herein relates to a novel nanoparticle that can cross the blood-brain barrier and form a bond with amyloid plaques and other related protein aggregates for detection by magnetic resonance imaging (MRI). The compositions, methods of making, and methods of use set forth herein also provide a non-invasive means for diagnosing Alzheimer's disease at an early stage.

A rare earth-based nanoparticle magnetic resonance contrast agent and a preparation method thereof are provided. The rare earth-based nanoparticle magnetic resonance contrast agent is rare earth-based inorganic nanoparticles having the surfaces coated with hydrophilic ligands. The rare earth-based nanoparticles are first obtained by a high-temperature oil phase reaction, and then the surfaces thereof are coated with hydrophilic molecules to obtain the rare earth-based nanoparticle magnetic resonance contrast agent. Compared with the existing clinical contrast agent, the magnetic resonance contrast agent of the present invention has a greatly improved relaxivity, a good imaging effect, a low required injection dose, and long in vivo residence time. In addition, the rigid structure of the inorganic nanoparticles can effectively reduce the leakage possibility of gadolinium ions.

The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.

Composition methods and kits for diagnosing and treating tumors within a subject. The compositions disclosed comprise: a gold nanoparticle; PEG or derivatives thereof, wherein said PEG or derivatives thereof have a molecular weight of 400 to 1500 Dalton; and a 2-Deoxy-D-glucose, wherein the PEG or derivatives thereof are linked to the gold nanoparticle and to said 2-Deoxy-D-Glucose, and wherein the 2-Deoxy-D-Glucose is linked to the PEG or derivatives thereof at the 2-Carbon position of the 2-Deoxy-D-Glucose.

The invention teaches a method of efficiently dewatering a microcapsule slurry to form a water re-suspendable filter cake of microcapsules. The process comprises providing an aqueous slurry of microcapsules dispersed in an aqueous solution; adding an agglomeration agent and dispersing the agglomeration agent into the aqueous slurry; adjusting the pH to a pH level sufficient to agglomerate the dispersed microcapsules; and filtering the aqueous slurry of microcapsules by gravity, vacuum or pressure filtration to thereby form a filter cake of dewatered microcapsules. The agglomeration agent is sodium polyphosphate, sodium tetrapolyphosphate, sodium hexametaphosphate, and/or sodium tripolyphosphate; or with anionic microcapsules or coatings even alkaline earth metal salts such as magnesium chloride, calcium chloride or barium chloride, or even aluminum salt such as aluminum chloride.

The invention provides systems and methods for providing a diagnostic examination to a patient, including, but not limited to a determination of the permeability of a patients' body cavity.

The invention provides systems and methods for providing a diagnostic examination to a patient, including, but not limited to a determination of the permeability of a patients' body cavity.

The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents can be used to image angiogenesis, inflammation or other physiological processes in a subject.

A method for preparing chitosan-coated magnetic nanoparticles for protein immobilization includes forming ferrous ferric oxide (Fe.sub.3O.sub.4) nanoparticles by co-precipitation and coating the nanoparticles with chitosan in the presence of glutaraldehyde. The Fe.sub.3O.sub.4 nanoparticles can be coated by dispersing ferrous ferric oxide (Fe.sub.3O.sub.4) nanoparticles into a solution comprising chitosan and acetic acid, adding a surfactant, adding excess 50% glutaraldehyde solution, and washing the nanoparticles with a solvent. The chitosan coated ferric oxide (Fe.sub.3O.sub.4) nanoparticles can be used to immobilize proteins or other biomolecules.