A biometric method includes: a step (1) for administering, to a target organism from the outside thereof, one of (i) a target molecule A having both an unpaired electron and a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of .sup.19F, and (ii) a target molecule B and a radical molecule C, the target molecule B having no unpaired electron, and further having a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of .sup.19F, the radical molecule C having an unpaired electron; and a step (2) for causing electron spin resonance in the unpaired electron of the target molecule A or the radical molecule C by irradiating electromagnetic waves to the target organism, subsequently triggering nuclear magnetic resonance in the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of .sup.19F in one of the target molecule A and the target molecule B, and further, measuring nuclear magnetic resonance signals. The step (2) is carried out in a magnetic field having such an intensity that the nuclear magnetic resonance signals of the magnetic resonance nucleus in one of the target molecule A and the target molecule B are degenerated, the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of .sup.19F. The biometric method makes it possible to measure low-sensitivity magnetic resonance nucleus such as .sup.13C, .sup.15N, and .sup.31P, which are important nuclides present in organism, with performance equal to or over that of a high-field MRI device.

The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds.

The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds.

A method tor the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

A method tor the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds.

The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds.

A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

A biometric method includes: a step (1) for administering, to a target organism from the outside thereof, one of (i) a target molecule A having both an unpaired electron and a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of .sup.19F, and (ii) a target molecule B and a radical molecule C, the target molecule B having no unpaired electron, and further having a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of .sup.19F, the radical molecule C having an unpaired electron; and a step (2) for causing electron spin resonance in the unpaired electron of the target molecule A or the radical molecule C by irradiating electromagnetic waves to the target organism, subsequently triggering nuclear magnetic resonance in the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of .sup.19F in one of the target molecule A and the target molecule B, and further, measuring nuclear magnetic resonance signals. The step (2) is carried out in a magnetic field having such an intensity that the nuclear magnetic resonance signals of the magnetic resonance nucleus in one of the target molecule A and the target molecule B are degenerated, the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of .sup.19F. The biometric method makes it possible to measure low-sensitivity magnetic resonance nucleus such as .sup.13C, .sup.15N, and .sup.31P, which are important nuclides present in organism, with performance equal to or over that of a high-field MRI device.