High throughput cell free protein synthesis methods and systems are provided for expression of active, mature enzymes and proteins derived from zymogens and proproteins. Zymogens and proproteins are expressed in their mature, active form in a cell free expression system, without cleavage of a pro-sequence to produce the active polypeptide.

The present invention relates to a composition for preventing hair loss and, more specifically, to a compound having a structure in which Minoxidil and a peptide are chemically connected, and to a pharmaceutical composition or cosmetic composition for preventing hair loss or promoting hair growth comprising the compound. The compound having a structure in which Minoxidil and a peptide are chemically connected according to the present invention has not only excellent physiological activity such as hair loss reduction, hair growth promotion or cell growth promotion, but also excellent stability in water, and can therefore be useful as a composition for preventing hair loss and promoting hair growth.

Described herein are oral care compositions comprising a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, together with particular co-polymers as additional excipients; including some embodiments which further comprise a calcium abrasive.

Disclosed are: a co-emulsified composition containing different emulsification particle sizes; and a method for preparing the same. The co-emulsified composition contains an amphipathic anisotropic power and a surfactant, thereby allowing emulsification particles with different sizes to coexist in one dosage form, and thus a co-emulsified composition can be provided that simultaneously implements two or more feelings of use or physical characteristics.

A chemically anisotropic powder with improved emulsion dispersion stability, and a cosmetic composition containing the same are disclosed in the present specification. The chemically anisotropic powder has a first polymer spheroid and a second polymer spheroid coupled in such a structure in which one polymer spheroid at least partially penetrates the other polymer spheroid, wherein any one of the first polymer spheroid and the second first polymer spheroid comprises a polymer containing siloxane, and one or more of the first polymer spheroid and the second first polymer spheroid are negatively or positively charged, thereby having effects of preventing phase separation even with a minimum amount of a thickening agent and enabling a toner type low-viscosity form containing a high oil content, the toner type low-viscosity form having yet to be applied.

A topical skincare composition that includes (A) a reducing sugar, (B) an optionally substituted C.sub.8-12 alkyl sulfonate, and (C) a carrier. The composition may further include an aromatic sulfonate. A method for enhancing color appearance (e.g., hue angle, lightness, saturation) of skin, which involves applying the topical skincare composition onto the skin is also specified. The topical skincare composition can provide a deep, rich, long lasting artificial tan with customizable hue preservation or adjustment when applied onto the skin.

The invention includes an UV absorbing complex polyol polyester polymer that is the product of a reaction scheme that includes: (i) the esterification of a polyol and a dianhydride, wherein the esterification is carried out under conditions that facilitate substantially only anhydride opening, to form a polyester polymer comprising at least two pendant carboxylic groups, and at least two hydroxyl groups; and (ii) the reaction of at least one pendant carboxylic group and at least one terminal hydroxyl group of the polyester polymer with an epoxide having a functional group, wherein the epoxide comprises an UV absorbing moiety.

Also included are linear UV absorbing complex polyol polyester polymers represented by Formula (XI):

##STR00001##

wherein R.sup.3 is independently selected from an UV absorbing moiety; R.sup.4 and R.sup.5 are each independently selected from a hydrocarbon group, and n is an integer of 1 to 1000.

A crosslinked UV absorbing complex polyol polyester polymer that is reaction product of a random copolyesterification esterification reaction and/or the esterification product of: a monofunctional carboxylic acid and/or ester that comprises an UV absorbing moiety, at least one of a diol, a polyol, a diacid and/or an ester is also included within the scope of the invention. The resulting polymer has an UV absorbing functionality of greater than 2.0.

The present invention relates to a Trolox-peptide conjugate having a structure in which Trolox and a peptide are chemically bonded. The Trolox-peptide conjugate not only very effectively inhibits the activity of 5α-reductase, but also inhibits the death of papilla cells and keratinocytes, promotes the growth thereof, and has antioxidative effects, and thus can remarkably promote hair formation while avoiding or preventing hair loss.

The present invention relates to a lipolysis composition comprising a biocompatible polymer that is surface-modified by an adipocyte-targeting or cell-penetrating peptide; and surface-modified gas-generating nanoparticles that contain fine-grained calcium carbonate crystals enclosed in the biocompatible polymer.

The present application relates to silicone compounds, compositions, packaged products and displays comprising such silicone compounds, and processes for making and using such compositions, packaged products and displays comprising such compositions. Such compositions have improved deposition and retention properties that may impart improved benefit characteristics to a composition and/or situs yet which changes its hydrophilicity/charge when desired.