An oral care implement having electrodes thereon. In one aspect, the oral care implement may include a handle and a head, the head having a front surface and an opposite rear surface. A plurality of tooth cleaning elements may extend from the front surface of the head. A soft tissue cleaner may be located on the rear surface of the head, the soft tissue cleaner including a protuberance field. A first electrode and a second electrode are each operably coupled to a power source to have opposite electrical charges. The first and second electrodes may be spaced apart from one another and substantially surround the protuberance field. In other embodiments, the first and second electrodes may be embedded within or otherwise located within the protuberance field.

An oral care implement having electrodes thereon. In one aspect, the oral care implement may include a handle and a head, the head having an outer surface. A plurality of tooth cleaning elements extend from the head. At least one oral care agent dispenser is located on the head. A first electrode and a second electrode are located on the head and operably coupled to a power source to have opposite electrical charges. In some embodiments at least one of the first and second electrodes may be a sacrificial electrode. The oral care agent dispenser may be an outlet that is coupled to an oral care fluid in a reservoir and/or a solid release polymer that releases an oral care agent over time during use of the oral care implement.

The present invention relates to an electroporation process for delivering a composition through human keratin materials, the composition comprising at least one hydroxy acid compound, the electroporation process involving exposing the composition in contact with said keratin materials to pulse trains of a pulsed electric current, the pulsed electric current being provided by an electroporation device having at least one electrode and at least one counterelectrode, the pulse trains of the pulsed electric current repeating at a frequency of between 0.1 Hz and 1 kHz, the pulse trains each having a duration (T.sub.on) of between 0.001 s and 2 s, and the pulsed electric current having a voltage amplitude ranging from 20 V to 250 V and a current ranging from 0.1 mA to 10 mA.

A iontophoresis method (700) is described for delivering vitamin C through the skin of a biological subject, the method comprising applying (702) a selected current profile, either continuous direct current or pulsed current or a combination of both to a biological subject. A iontophoresis composition is further described, comprising one or more of vitamin C, vitamin C derivatives, ions of vitamin C and ions of vitamin C derivatives and further comprising a silicon material and water. A ionotophoresis kit for carrying out the iontophoresis method is also disclosed. The application further describes a iontophoresis device comprising an electrode assembly and circuitry configured to concurrently generate a continuous direct current stimulus and a pulsed current stimulus; a corresponding iontophoresis method for delivering a cosmetic composition to a biological subject is also disclosed.

The invention relates to an eyelash coating compositions comprising water, at least one polyelectrolytic compound, at least one film-forming agent, at least two waxes, and an emulsification system comprising low HLB emulsifier(s) (HLB value less than 8) and high HLB emulsifier(s) (HLB value greater than 16), as well as to methods of using such compositions.

The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

A cosmetic and/or therapeutic treatment of tissue, such as tooth, is disclosed that effects, for instance, whitening and tissue re-building through mineralisation. Further, a method of performing iontophoresis utilizing an aqueous composition of a remineralising agent to achieve mineralisation is disclosed, as well as a kit for performing the mineralization or re-mineralization.

A cosmetic and/or therapeutic treatment of tissue, such as tooth, is disclosed that effects, for instance, whitening and tissue re-building through mineralisation. Further, a method of performing iontophoresis utilizing an aqueous composition of a remineralising agent to achieve mineralisation is disclosed, as well as a kit for performing the mineralization or re-mineralisation.

The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

To provide acidic electrolyzed water having disinfecting power for a long period of time (for example, six months or more), and a production method for this acidic electrolyzed water. The acidic electrolyzed water has an effective chlorine concentration equal to or greater than 15 ppm, and contains an acid salt of an inorganic acid.