The present invention relates to a composition for the protection against solar radiation, consisting of an organic matrix, preferably a gelatin, and hydroxyapatite nanoparticles modified by the substitution of part of the phosphorus with titanium, and part of the calcium with iron.

Disclosed herein are improved methods for the synthesis of stannous pyrophosphate, as well as improved methods for the manufacture of oral care compositions comprising stannous pyrophosphate.

A method of lyophilizing exosomes using a cryoprotectant comprising methionine, mannitol and trehalose is disclosed. The lyophilized exosome product shows a good appearance which maintains a porous sponge shape without forming ice crystals. In addition, the lyophilized exosome product can be applied to a pharmaceutical composition, a skin external preparation and a cosmetic composition. For example, the lyophilized exosome product can be used as a solution obtained by simply mixing it with a diluent.

Disclosed herein are improved methods for the synthesis of stannous pyrophosphate, as well as improved methods for the manufacture of oral care compositions comprising stannous pyrophosphate.

The lyophilized formulation of stem cell-derived exosomes and the anti-inflammatory composition including the same as an active ingredient is able to stabilize stem cell-derived exosomes and exhibit excellent anti-inflammatory effects, and particularly, exhibit remarkable anti-inflammatory effects as compared with not-lyophilized stem cell-derived exosomes isolated and purified from conditioned media of stem cells. Therefore, the lyophilized formulation of stem cell-derived exosomes and the anti-inflammatory composition including the same as an active ingredient is able to effectively prevent, suppress, alleviate, ameliorate or treat inflammatory response or inflammatory diseases.

One aspect of the invention provides a method for freeze-drying surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; partially submerging the vials in a chilled water bath, wherein the water bath has a sub-freezing temperature; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. Another aspect of the invention provides a method for annealing surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; passing the vials in and out of liquid nitrogen (LN.sub.2) until the mixture is frozen; holding the vials at 20 C.; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials.

The present invention provides a composition for lipolysis, for example a pharmaceutical composition for preventing or treating obesity including localized fat deposits (LFD), comprising certain phosphocholine derivatives or pharmaceutically acceptable salt thereof. The pharmaceutical composition of the present invention shows an excellent lipolytic activity as well as a uniform lipolytic activity. And also, the pharmaceutical composition of the present invention can minimize side effects such as inflammation, tissue necrosis, etc., at the administered site. In addition, the pharmaceutical composition of the present invention has excellent storage stability.

A refillable unit dose package for frozen cosmetic or personal care products that can provide a chilling effect during application. The main components of the package are a reservoir and an applicator. The applicator comprises a handle and an applicator head depending from the handle. In use, a product in the reservoir is frozen, which causes the product to bond to the applicator head. The handle is used to lift the frozen product out of the reservoir, and draw the frozen product over the skin. As it melts from the heat of the skin, the product can be spread on the skin. The reservoir is refillable by a consumer.

Freeze dried active compositions are described. The compositions comprise less than 6.5% by weight water and they may be hydrated or added to end use compositions in order to yield compositions for delivering superior topical benefits to consumers.

Disclosed are a scrub sponge and a preparation method therefor. The method for preparing the scrub sponge includes the operations of: obtaining a first mixture by stirring alkalizer, porogen, konjac powder, scrub granule and water, and filling the first mixture into a mold to form a preform, where the preform includes a first sponge layer; forming a parison by sequentially cooking and freezing the preform; and sequentially unfreezing, dehydrating and drying the parison to obtain the scrub sponge.