The present invention relates to the synergistic effect of calcium hydroxyapatite particles and hyaluronic acid on the bio-stimulation. The invention refers to an injectable composition comprising one or more types of calcium hydroxyapatite particles and hyaluronic acid and to a method for preparing such injectable composition. Furthermore, it relates to a cosmetic method for improving appearance of the skin and/or contour of a subject by means of the injectable composition. Moreover, the invention refers to the injectable composition for use in a method of treating a pathologic condition associated with pathologic deterioration of connective tissue.

Disclosed herein are soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. Some of the hyaluronic acid-based compositions can include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. Compared to conventional compositions that include lidocaine, some of the hyaluronic acid-based compositions disclosed herein can have an enhanced stability, for example, when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such compositions are also provided.

The disclosure provides silk fibroin compositions for stimulating collagen expression in a subject and methods of use thereof.

The present disclosure relates to the cosmetology field, in particular to an activated revitalizing lotion and its preparation method and application. A preparation method of an activated revitalizing lotion comprises the steps of: mixing an isolated blood sample, ozone-oxygen mixture and sodium citrate, and centrifuging the mixed blood sample at 1800-2000 r/min for 9-10 min to obtain a plasma supernatant for use as an activated revitalizing lotion; the ozone-oxygen mixture has an ozone concentration of 42.8-171.4 μg/L and added in an amount of 2.3-3.2 L/1 L of the isolated blood sample; and sodium citrate is added in an amount of 0.2-0.3 mg/1 L of the isolated blood sample. The activated revitalizing lotion prepared by the preparation method of the present disclosure shows improved effect in repair and revitalization of skin or subcutaneous tissues.

Methods for transdermal delivery of glycosaminoglycans (GAGs) are disclosed, comprising applying ultrasound to the skin followed by topical administration of one or more GAGs optionally complexed with a polysaccharide carrier. When GAG is hyaluronic acid complexed with a modified starch, a transdermal delivery method is provided for facilitating delivery of high molecular weight hyaluronic acid into deep layers of the epidermis and to the dermis in a non-invasive, convenient and painless way. This transdermal delivery method may be applied in treatment of skin aging phenomena associated with collagen and/or hyaluronic acid depletion or loss.

Disclosed is a composition for ameliorating, preventing or treating an autoimmune skin disease, containing a Musan box (Sphallerocarpus gracilis) extract or a fraction thereof as an active ingredient.

Disclosed are skin lightening personal care compositions comprising hexylresorcinol and licorice extract, wherein hexylresorcinol is present in an amount of from 0.00001% to 1% by weight of the composition and licorice extract is present in an amount of from 0.00001% to 0.1% by weight of the composition, as well as methods of using these compositions.

An hydrogel comprising chitosan and two weak bases having different pKb values. In some embodiments, one of the weak bases if sodium hydrogen carbonate (SHC). Also, use of the hydrogel in medical and cosmetic treatments.

The present invention concerns polymer particles made from poly(lactic-co-glycolic acid) (PLGA) polymer, poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA) copolymer, or the mixture of same, combined with hyaluronic acid molecules or hyaluronic acid salts, and the method for preparing same. The present invention also concerns injectable pharmaceutical or cosmetic compositions comprising such polymer particles, the method for preparing such compositions, and the use thereof for medical purposes, in particular for the prevention and/or treatment of musculoskeletal diseases, diseases and traumatic conditions of the skin, oral disorders, vaginal mucosa dryness and urinary infections or cystitis, dryness of the eye membrane and eye infections, obesity, and the use of same to combat ageing of the skin and/or for repairing the dermal tissue (mesotherapy).

The present invention relates to a process for preparing a crosslinked gel of at least one polysaccharide or a salt thereof, comprising at least the steps consisting in: a) providing a solution formed from an aqueous medium comprising at least said polysaccharide(s) or a salt thereof in a non-crosslinked form, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt; b) crosslinking the solution from step a) and, where appropriate; c) recovering said crosslinked gel formed.