The present invention provides an indicator useful in confirming successful sterilisation and/or nucleic acid decontamination by ethylene oxide (EtO) treatment. The invention also provides a label comprising said indicator and methods for use of the indicator and label in a method of EtO treatment.

A method of sterilizing an article includes receiving the article in a sterilization chamber. The method also includes applying a vacuum to a first pressure less than 100 torr. The method also includes introducing a sterilant into the sterilization chamber. The method also includes maintaining the first pressure in the sterilization chamber for a first period of time. The method also includes venting the sterilization chamber to a second pressure less than 100 torr. The method also includes maintaining the second pressure. The method also includes venting the sterilization chamber to a third pressure. The method also includes maintaining the third pressure. The method also includes venting the sterilization chamber to atmospheric pressure. The method further includes between venting and maintaining steps applying a vacuum to a fourth pressure less than 100 torr, introducing additional sterilant, and maintaining the fourth pressure.

A method of sterilizing an article includes receiving the article in a sterilization chamber. The method also includes applying a vacuum to a first pressure less than 100 torr. The method also includes introducing a sterilant into the sterilization chamber. The method also includes maintaining the first pressure in the sterilization chamber for a first period of time. The method also includes venting the sterilization chamber to a second pressure less than 100 torr. The method also includes maintaining the second pressure. The method also includes venting the sterilization chamber to a third pressure. The method also includes maintaining the third pressure. The method also includes venting the sterilization chamber to atmospheric pressure. The method further includes between venting and maintaining steps applying a vacuum to a fourth pressure less than 100 torr, introducing additional sterilant, and maintaining the fourth pressure.

An ultraviolet device is provided, which includes a gas jetting module, a flow rate adjustment module, an ultraviolet module and a first gas channel. The gas jetting module includes an upper panel, a lower panel and a frame. The upper panel is disposed on the upper side of the frame. The lower panel is disposed on the lower side of the frame and includes one or more gas outlets. A gas chamber is formed between the upper panel, lower panel and frame. The first gas channel is connected to the gas jetting module. The flow rate adjustment module is connected to the first gas channel and adjusts the flow rate of the gas inputted into the gas chamber via the first gas channel. The ultraviolet module includes an ultraviolet light source and is connected to the gas jetting module.

An ultraviolet device is provided, which includes a gas jetting module, a flow rate adjustment module, an ultraviolet module and a first gas channel. The gas jetting module includes an upper panel, a lower panel and a frame. The upper panel is disposed on the upper side of the frame. The lower panel is disposed on the lower side of the frame and includes one or more gas outlets. A gas chamber is formed between the upper panel, lower panel and frame. The first gas channel is connected to the gas jetting module. The flow rate adjustment module is connected to the first gas channel and adjusts the flow rate of the gas inputted into the gas chamber via the first gas channel. The ultraviolet module includes an ultraviolet light source and is connected to the gas jetting module.

An isolation chamber includes a plurality of walls and ceiling defining an internal chamber and a first and second door. The doors seal engagement with the walls. A fan filter unit is arranged to extract air from the internal chamber. The isolation chamber is arranged to couple to a doorway, and the coupling arranged to provide an airtight seal about the doorway.

Ozone generating machine (OGM) for generating ozone in a ship, comprising: an ozone generator with at least two electrodes separated by an ozonizing gap and at least a gas inlet for receiving a feed gas containing dioxygen, and a gas outlet for exhausting gas comprising ozone to an ozone circuit of the ship, a main liquid cooling circuit (CWP, CWT), with at least a cooling portion in the ozone generator, to be connected with a cooling circuit of a ship, a liquid-liquid heat exchanger (LLHEX) connected with the main liquid cooling circuit (CWP, CWT), and an electrical closed cabinet (ECB) comprising an electric current converter (ECV),
characterized in that the ozone generating machine (OGM) further comprises a closed loop cooling liquid circuit (CLC) comprising a converter liquid cooling portion (CECV) arranged to cool the electric current converter (ECV) and connected with the liquid-liquid heat exchanger (LLHEX).

Methods are provided that include positioning a disinfection apparatus in proximity to a cabinet, wherein the disinfection apparatus has a base supporting a germicidal source and the base includes components operationally coupled to the germicidal source for operating the germicidal source. The method further includes inserting the germicidal source into the cabinet such that at least a portion of the base is retained exterior to the cabinet and is operationally coupled to the germicidal source. Moreover, the method includes placing one or more items into the cabinet, closing the cabinet with the germicidal source and the one or more items in the cabinet and the base of the disinfection apparatus exterior to the cabinet, and then subsequently starting the disinfection source such that the germicidal source emits a germicide into the cabinet. Systems and cabinets used to conduct the aforementioned methods are also provided.

Methods are provided that include positioning a disinfection apparatus in proximity to a cabinet, wherein the disinfection apparatus has a base supporting a germicidal source and the base includes components operationally coupled to the germicidal source for operating the germicidal source. The method further includes inserting the germicidal source into the cabinet such that at least a portion of the base is retained exterior to the cabinet and is operationally coupled to the germicidal source. Moreover, the method includes placing one or more items into the cabinet, closing the cabinet with the germicidal source and the one or more items in the cabinet and the base of the disinfection apparatus exterior to the cabinet, and then subsequently starting the disinfection source such that the germicidal source emits a germicide into the cabinet. Systems and cabinets used to conduct the aforementioned methods are also provided.

A flexible, sterilizable pouch includes a first gas-impermeable web, a second gas-permeable web, and the third gas-impermeable web. The webs are arranged and sealed to form a cavity portion of the pouch and a header portion of the pouch. The header portion of the pouch is gas-permeable through the second gas-permeable web. The cavity portion of the pouch is configured to hold a medical device for sterilization and is configured to be sealed from the header portion after sterilization, thereby making the cavity portion gas-impermeable. The header is also configured to be removed from the pouch, leaving the cavity portion.