An ozone treatment system which is usable in enclosed or confined spaces for the inactivation of pathogens such as bacteria and viruses in these spaces.

Syringe assemblies comprising a first cap and a second cap to ensure sterilization of the fluid path without the need for external packaging are described. Also described are methods of sterilizing the fluid path of a syringe assembly.

A fluid plug for use with sterile processes such as the manufacture or production of pharmaceuticals and biologics is disclosed. The fluid plug is made of a material or materials that will tolerate sterilizing processes such as gamma irradiation. The fluid plug is used to selectively plug the ends of flexible polymer conduits that may be connected to fluids, reagents, or products used or generated as part of the manufacturing process. Also disclosed is the use of the plugs in combination with a series of valves in a block-and-bleed arrangement to enable the sterile transfer and connection of fluids, reagents, or products within a process flow.

The present invention relates to an apparatus (10) for filling containers in a sterile environment, comprising a filling unit (40) configured to fill containers with sterilized liquids or powders in a sterile environment comprising interchangeable parts characteristic of each production run; a washer sterilizer (20) configured to wash, sterilize, decontaminate, dry in one single process said interchangeable parts of the filling unit (40) before each run for filling the unit (40). The washer sterilizer (20) is directly coupled to the filling unit (40) and is configured to aseptically transfer the interchangeable parts directly to the filling unit (40).

An HVAC duct ozone generator includes at least two ozone generation plate stacks, where each plate stack includes at least two independently electrically addressable plate groupings, where a primary plate grouping includes fewer ozone generation plates than a secondary plate grouping. Thus, the generator includes at least four independent ozone generation control channels to energize the primary and secondary plate groupings of each of the at least two plate stacks. The number of plates in a plate grouping may optionally be altered to reduce the ozone generation capacity of the primary plate grouping in relation to the secondary plate grouping through the movement of resistive collars between the stacked ozone generation plates.

A gas sterilizable syringe includes an enclosure having walls that define a fluid chamber. A flowable material is disposed within the fluid chamber of the enclosure. A plunger is assembled with the enclosure and is moveable toward a distal end of the enclosure for dispensing the flowable material. One or more apertures are formed in at least one of the walls of the enclosure. A gas permeable barrier covers at least one of the apertures formed in at least one of the walls of the enclosure for enabling sterilization gases to pass through the at least one aperture covered by the gas permeable barrier while preventing the flowable material from passing through the at least one of aperture. The gas permeable barrier is permeable to the sterilization gases and impermeable to the flowable material disposed within the fluid chamber of the enclosure.

A method is provided for vaporized hydrogen peroxide cleaning of a chamber. The method includes altering a temperature of air in the chamber from an initial temperature to a sterilization temperature over a first time period. The method also includes injecting vaporized hydrogen peroxide into air in the chamber to alter a relative humidity of hydrogen peroxide vapor in the chamber to a sterilization level over the first time period. The method also includes maintaining the temperature at the sterilization temperature and the relative humidity at the sterilization level over a second time period. The method also includes reducing the relative humidity from the sterilization level to a safe level over a third time period. In one embodiment, the method is provided for vaporized hydrogen peroxide cleaning of an interior chamber of an incubation container. In other embodiments, the incubation chamber featured in the method is provided.

A method for sterilizing closure elements (3) for packaging containers (1), wherein the closure elements (3) are collected individually by a holding mechanism (25) in the region of a sterile chamber (12) and are placed onto an opening (4) of a filled packaging container (1) and connected to the latter, and wherein the closure elements (3), while being conveyed inside the sterile chamber (12), are treated by means of at least one sterilizing medium (6, 7, 52) during a sterilizing process.

In various embodiments, methods of treating a space to reduce a concentration of volatile organic compounds present in the space using chlorine dioxide are provided. A method can include application of aqueous and gaseous chlorine dioxide solutions within the space or to materials located within the space. Treatment of materials that emit volatile organic compounds with chlorine dioxide can reduce the emission rate or shorten the volatile organic compound emission cycle of the material. Soft surface substrates such as carpeting materials can be treated with chlorine dioxide to reduce volatile organic compound emission and/or to reduce the number of microorganisms present in the material.

In various embodiments, methods of treating a space to reduce a concentration of volatile organic compounds present in the space using chlorine dioxide are provided. A method can include application of aqueous and gaseous chlorine dioxide solutions within the space or to materials located within the space. Treatment of materials that emit volatile organic compounds with chlorine dioxide can reduce the emission rate or shorten the volatile organic compound emission cycle of the material. Soft surface substrates such as carpeting materials can be treated with chlorine dioxide to reduce volatile organic compound emission and/or to reduce the number of microorganisms present in the material.