This invention relates to comfortable ophthalmic devices and methods of producing such devices.

This invention relates to comfortable ophthalmic devices and methods of producing such devices.

An objective of the present invention is to provide a method for easily manufacturing a hydrophilized medical device of superior durability. In order to achieve the abovementioned objective, a method for manufacturing a medical device according to the present invention comprises a step for heating an aqueous package fluid, wherein, in the heating step, the aqueous package fluid contains one or more types of hydrophilic polymer, heating is performed with a substrate of the medical device at least partially is contact with the aqueous package fluid, and the following conditions (a) through (c) are all met. (a) The hydrophilic polymer is a (meth)acrylamide (co)polymer comprising two substituents comprising two or more carbon atoms on a nitrogen atom. (b) The mass % concentration of the hydrophilic polymer in the aqueous package fluid is in a range of 0.0001-30 mass %. (c) The pH of the aqueous package fluid after the heating step is in a range of 6.1-8.0.

An objective of the present invention is to provide a method for easily manufacturing a hydrophilized medical device of superior durability. In order to achieve the abovementioned objective, a method for manufacturing a medical device according to the present invention comprises a step for heating an aqueous package fluid, wherein, in the heating step, the aqueous package fluid contains one or more types of hydrophilic polymer, heating is performed with a substrate of the medical device at least partially is contact with the aqueous package fluid, and the following conditions (a) through (c) are all met. (a) The hydrophilic polymer is a (meth)acrylamide (co)polymer comprising two substituents comprising two or more carbon atoms on a nitrogen atom. (b) The mass % concentration of the hydrophilic polymer in the aqueous package fluid is in a range of 0.0001-30 mass %. (c) The pH of the aqueous package fluid after the heating step is in a range of 6.1-8.0.

A packaging system for storing ophthalmic devices such as contact lenses and methods for packaging such ophthalmic devices with solutions is disclosed. The packaging system contains an unused, ophthalmic device in an aqueous packaging solution comprising tris(hydroxymethyl)aminomethane or a salt thereof; wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9.

A packaging system for storing ophthalmic devices such as contact lenses and methods for packaging such ophthalmic devices with solutions is disclosed. The packaging system contains an unused, ophthalmic device in an aqueous packaging solution comprising tris(hydroxymethyl)aminomethane or a salt thereof; wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9.

This invention relates to comfortable ophthalmic devices and methods of producing such devices by treating unhydrated, polymerized ophthalmic lens with a polymeric wetting agent, wherein the ophthalmic lens formulation does not comprise said wetting agent prior to its polymerization.

This invention relates to comfortable ophthalmic devices and methods of producing such devices by treating unhydrated, polymerized ophthalmic lens with a polymeric wetting agent, wherein the ophthalmic lens formulation does not comprise said wetting agent prior to its polymerization.

The invention is generally related to a method for producing, in a consistent manner, SiHy contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, the base coating is formed by having two solution coating steps separated by at least one rinsing step with a buffered saline or pH controlled solution. The durability of the hydrogel coatings on resultant silicone hydrogel contact lenses can be improved significantly and will not vary with the optical power (i.e., the center thickness) of the SiHy contact lens under coating.

The invention is generally related to a method for producing, in a consistent manner, SiHy contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, the base coating is formed by having two solution coating steps separated by at least one rinsing step with a buffered saline or pH controlled solution. The durability of the hydrogel coatings on resultant silicone hydrogel contact lenses can be improved significantly and will not vary with the optical power (i.e., the center thickness) of the SiHy contact lens under coating.