The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal/anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.

Described herein is a single-use cleansing device for cleaning a contact lens, and a cleansing solution. The single-use cleansing device includes a first compartment and a second compartment, wherein the first compartment comprises a wipe, and the second compartment comprises a cleansing solution comprising Euphrasia.

Described herein is a single-use cleansing device for cleaning a contact lens, and a cleansing solution. The single-use cleansing device includes a first compartment and a second compartment, wherein the first compartment comprises a wipe, and the second compartment comprises a cleansing solution comprising Euphrasia.

The objective of the present invention is to provide a contact lens solution that is safer to eyes such that it has little or no effects on eye tissue and has the versatility that makes the solution applicable to a wide range of contact lenses, while exhibiting desirable anti-Acanthamoeba activity. The objective is achieved by the anti-Acanthamoeba contact lens solution containing a cationic polymer having an average molecular weight in a range of 150,000 to 1,600,000 and having in its molecule a diallyldimethylammonium chloride unit and an inorganic salt.

The objective of the present invention is to provide a contact lens solution that is safer to eyes such that it has little or no effects on eye tissue and has the versatility that makes the solution applicable to a wide range of contact lenses, while exhibiting desirable anti-Acanthamoeba activity. The objective is achieved by the anti-Acanthamoeba contact lens solution containing a cationic polymer having an average molecular weight in a range of 150,000 to 1,600,000 and having in its molecule a diallyldimethylammonium chloride unit and an inorganic salt.

Synthetic peptides comprising a sequence of amino acids XnVm, wherein X represents positively charged amino acid, Y represents hydrophobic amino acid, and both n and m are greater than 2 are disclosed. In accordance with the purposes of the disclosed compositions and methods, as embodied and broadly described herein, the disclosed subject matter relates to synthetic antimicrobial peptides and methods of making and using same.

Synthetic peptides comprising a sequence of amino acids XnVm, wherein X represents positively charged amino acid, Y represents hydrophobic amino acid, and both n and m are greater than 2 are disclosed. In accordance with the purposes of the disclosed compositions and methods, as embodied and broadly described herein, the disclosed subject matter relates to synthetic antimicrobial peptides and methods of making and using same.

A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes one or more conjugated glycosaminoglycans having a polymer backbone having a reactive functional moiety conjugated to an amine group having one or more moieties that inhibit and/or prevent one or more of oxidation and hydrolytic degradation of the polymer backbone during use in the eye; wherein the aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes one or more conjugated glycosaminoglycans having a polymer backbone having a reactive functional moiety conjugated to an amine group having one or more moieties that inhibit and/or prevent one or more of oxidation and hydrolytic degradation of the polymer backbone during use in the eye; wherein the aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

An ophthalmically compatible solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; (c) sodium chloride, potassium chloride or any combination thereof; and (d) one or more buffers.