The invention provides contact lens storage, cleaning and treatment compositions comprising nonionic surfactants. The invention further provides methods for treating enhancing contact lens wear time and comfort, reducing contact lens deposits and treating dry eye via contact lenses.

A method for introducing an active compound into a soft hydrated contact lens comprising the steps of: providing a hypotonic aqueous solution having an osmolarity value less than 150 mOsm and an effective quantity of that active compound, immersing the soft contact lens in the aqueous hypotonic solution, subjecting the contact lens immersed in the aqueous hypotonic solution to mechanical vibrations having a power greater than 100 mW for a predetermined time.

A method for introducing an active compound into a soft hydrated contact lens comprising the steps of: providing a hypotonic aqueous solution having an osmolarity value less than 150 mOsm and an effective quantity of that active compound, immersing the soft contact lens in the aqueous hypotonic solution, subjecting the contact lens immersed in the aqueous hypotonic solution to mechanical vibrations having a power greater than 100 mW for a predetermined time.

The present invention relates to an ophthalmic solution comprising 0.00001 to 10.0 weight percent of a simple saccharide, at least 0.00001 weight percent of a preservative, and not more than about 0.2 percent by weight chloride. The simple saccharide is chosen from the group consisting of: inositol; mannitol; sorbitol; sucrose; dextrose; glycerin; propylene glycol; ribose; triose; tetrose; erythrose; threose; pentose; arabinose; ribulose; xylose; xylulose; lyxose; hexose; allose; altrose; fructose; galactose; glucose; gulose; idose; mannose; sorbose; talose; tagatose; adlose; ketose; heptose; sedoheptulose; monosaccharides; disaccharides; sugar alcohols; xylitol; and polyol.

A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes ectoine or an ophthalmologically acceptable ectoine derivative. The aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

An ophthalmically compatible solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; (c) sodium chloride, potassium chloride or any combination thereof; and (d) one or more buffers.

Silicone hydrogel contact lenses are packaged in a packaging solution including an ophthalmically-acceptable concentration of a surfactant to provide a contact lens having a lower coefficient of friction compared to a control lens that is not packaged in the surfactant. The surfactant is a poly(ethylene oxide) (PEO)-containing surfactant having a molecular weight of up to about 6,000 daltons, or is an alkyl aryl-containing surfactant, or is both an alkyl aryl and PEO-containing surfactant having a molecular weight of up to about 6,000 daltons. Methods of manufacturing silicone hydrogel contact lenses are also described.

Silicone hydrogel contact lenses are packaged in a packaging solution including an ophthalmically-acceptable concentration of a surfactant to provide a contact lens having a lower coefficient of friction compared to a control lens that is not packaged in the surfactant. The surfactant is a poly(ethylene oxide) (PEO)-containing surfactant having a molecular weight of up to about 6,000 daltons, or is an alkyl aryl-containing surfactant, or is both an alkyl aryl and PEO-containing surfactant having a molecular weight of up to about 6,000 daltons. Methods of manufacturing silicone hydrogel contact lenses are also described.

The present invention relates to a liquid preparation for soft contact lenses, particularly hydrogel contact lenses or silicone hydrogel contact lenses. The liquid preparation for contact lenses according to the present invention contains a hydrolyzed hyaluronic acid derivative having a monoether of a linear or branched alkyl group or alkenyl group having 6 or more and 20 or less carbon atoms and glycerol in a side chain. The liquid preparation for soft contact lenses according to the present invention may contain at least one cationic bactericide selected from the group consisting of an alexidine salt, a chlorhexidine salt, a polyhexamethylene biguanide salt and a quaternary ammonium salt. The liquid preparation for soft contact lenses according to the present invention is capable of suppressing adsorption of a cationic bactericide to soft contact lenses, and suppressing occurrence of corneal staining in a wearer.

The invention contemplates a copolymer which is a graft or block copolymer useful to change the ocular surface temperature and other characteristics of biological or contact lens surfaces. Methods for use of these formulations and coatings to increase the temperature of the skin, mucous membranes, eye or eyelids will help treat many conditions including blepharitis and non-healing ulcers. Methods to decrease evaporation, improve wettability and stabilize the tear film, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to improve contact lens tolerability, are provided.