The present disclosure relates generally to wound dressing compositions and methods of manufacturing the wound dressing compositions of the present technology. The wound dressing composition includes a mixture of a collagen and/or chitosan and oxidized regenerated cellulose (ORC) with a layer of citric acid disposed therein. Also disclosed herein are methods of manufacturing such wound dressing compositions as well as kits including such wound dressing compositions.

The present disclosure provides wound dressing compositions that disrupt biofilm formation in a wound upon application. The wound dressing composition includes a first layer comprising a homogeneous mixture of a collagen, an oxidized regenerated cellulose (ORC), and at least one bacteria reducing active ingredient and a second layer comprising a homogeneous mixture of a collagen, an oxidized regenerated cellulose (ORC), a silver compound, and at least one bacteria reducing active ingredient, and the uses thereof. Also disclosed herein are kits comprising the wound dressing compositions of the present technology, and instructions for use.

Interpenetrating network hydrogels with independently tunable stiffness enhance tissue regeneration and wound healing.

This disclosure describes a wound sealing film containing a first layer having a first surface and a second surface, said first layer contains a first polymer composition, a second layer having a first surface and a second surface, said second layer contains an adhesive, and a third layer having a first surface and a second surface, said third layer contains a polymeric gel, wherein the second layer is positioned between the first layer and the third layer, method of making and using the wound sealing film. In some aspects, a wound sealing film can contain a first layer containing a first polymer composition, and a combined layer containing a polymeric gel and an adhesive.

An AM/AV material, comprising a topsheet layer comprising fibers comprising a topsheet polymer composition, a backsheet layer comprising fibers comprising a backsheet polymer composition; and an absorbent core configured therebetween, wherein the fibers of at least one of the layers, e.g., the topsheet layer, comprise an AM/AV compound, and wherein the fibers of the topsheet layer demonstrate a rewet value less than 5 g after a first water application and/or a Staph aureus efficacy log reduction greater than 2.6, as measured in accordance with ISO 20743:2013.

The present invention provides a hemostatic porous composite sponge comprising: i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.

The invention concerns a method to electrospin a composition to be electrospun, which comprises a compound to be electrospun and an electrospinning promoter. The method provides the steps of providing an electrospinning device comprising an electrospinning head and a collector; applying an electric field between the electrospinning head and the collector; and feeding the composition to be electrospun through the electrospinning head.

The invention concerns a method to electrospin a composition to be electrospun, which comprises a compound to be electrospun and an electrospinning promoter. The method provides the steps of providing an electrospinning device comprising an electrospinning head and a collector; applying an electric field between the electrospinning head and the collector; and feeding the composition to be electrospun through the electrospinning head.

A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.

A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.