Provided herein are microbial infection indicator devices, including dressing with indicators, standalone indicator inserts or disks that can be freely placed at a wound site or dressing, and applications thereof for displaying a visible or detectable signal to a user upon detection of an analyte or biomarker indicative of an infection, such as a color change.

Provided herein are microbial infection indicator devices, including dressing with indicators, standalone indicator inserts or disks that can be freely placed at a wound site or dressing, and applications thereof for displaying a visible or detectable signal to a user upon detection of an analyte or biomarker indicative of an infection, such as a color change.

A fibrin sealant product having a plurality of layers that each includes a dextran support and at least one fibrin sealant agent. The at least one fibrin sealant agent is placed on the dextran support to form each of the layers. The plurality of layers is placed in a stacked configuration to form the fibrin sealant product. A plurality of crimps is dispersed over a surface of the fibrin sealant product to retain the plurality of layers in a position with respect to each other.

A fibrin sealant product having a plurality of layers that each includes a dextran support and at least one fibrin sealant agent. The at least one fibrin sealant agent is placed on the dextran support to form each of the layers. The plurality of layers is placed in a stacked configuration to form the fibrin sealant product. A plurality of crimps is dispersed over a surface of the fibrin sealant product to retain the plurality of layers in a position with respect to each other.

An enzyme-degradable system for undergarments and feminine hygiene articles works to decompose the undergarments and feminine hygiene articles upon being triggered by bodily fluids, such as urine. The undergarment or feminine hygiene article comprises an absorbent core, an inner sheet of biodegradable material, and an outer sheet of biodegradable material. The core includes at least one of the following: a cellulose material, a wood pulp, a biodegradable and bioactive thermoplastic aliphatic polyester derived from renewable resources (polylactic acid plasticPLA), and a superabsorbent polymer (SAP). The inner and outer sheets comprise a plant based cellulosic nonwoven material. The cellulose enzyme decomposes the absorbent core, the inner sheet, and the outer sheet upon contact with a bodily fluid. The cellulose enzyme may include DIS-1018 Cellulose-AN, a pH buffer, and additives. Fasteners made from a resilient, biodegradable material help secure the undergarments and feminine hygiene articles to the body.

An enzyme-degradable system for undergarments and feminine hygiene articles works to decompose the undergarments and feminine hygiene articles upon being triggered by bodily fluids, such as urine. The undergarment or feminine hygiene article comprises an absorbent core, an inner sheet of biodegradable material, and an outer sheet of biodegradable material. The core includes at least one of the following: a cellulose material, a wood pulp, a biodegradable and bioactive thermoplastic aliphatic polyester derived from renewable resources (polylactic acid plasticPLA), and a superabsorbent polymer (SAP). The inner and outer sheets comprise a plant based cellulosic nonwoven material. The cellulose enzyme decomposes the absorbent core, the inner sheet, and the outer sheet upon contact with a bodily fluid. The cellulose enzyme may include DIS-1018 Cellulose-AN, a pH buffer, and additives. Fasteners made from a resilient, biodegradable material help secure the undergarments and feminine hygiene articles to the body.

A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (-, -, -amylase) are noted for the cleavage of the -glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that -amylase is effective in the debridement of devitalized tissue.

A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (-, -, -amylase) are noted for the cleavage of the -glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that -amylase is effective in the debridement of devitalized tissue.

The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.

The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.