Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.

Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.

This invention describes a wound dressing product for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies. The present invention pertains to the principle of continuous wound debridement which makes necrotic tissue more susceptible for removal and hence enhances progressive wound healing. The dressing contains an active ingredient, such as collagenase which serves to debride wounds in-situ. In the present invention purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.

This invention describes a wound dressing product for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies. The present invention pertains to the principle of continuous wound debridement which makes necrotic tissue more susceptible for removal and hence enhances progressive wound healing. The dressing contains an active ingredient, such as collagenase which serves to debride wounds in-situ. In the present invention purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.

This invention describes a wound dressing product for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies. The present invention pertains to the principle of continuous wound debridement which makes necrotic tissue more susceptible for removal and hence enhances progressive wound healing. The dressing contains an active ingredient, such as collagenase which serves to debride wounds in-situ. In the present invention purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.

This invention describes a wound dressing product for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies. The present invention pertains to the principle of continuous wound debridement which makes necrotic tissue more susceptible for removal and hence enhances progressive wound healing. The dressing contains an active ingredient, such as collagenase which serves to debride wounds in-situ. In the present invention purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.

The present invention relates to a process of enzymatic degradation of an absorbent structure, the absorbent structure being suitable for providing an absorbent core of a hygiene article, wherein the process comprises the step of contacting the absorbent structure with a solution comprising enzymes; wherein the absorbent structure comprises a polysaccharide superabsorbent polymer, such as a cellulose-based or a starch-based superabsorbent polymer.

The present invention relates to a process of enzymatic degradation of an absorbent structure, the absorbent structure being suitable for providing an absorbent core of a hygiene article, wherein the process comprises the step of contacting the absorbent structure with a solution comprising enzymes; wherein the absorbent structure comprises a polysaccharide superabsorbent polymer, such as a cellulose-based or a starch-based superabsorbent polymer.

A nanofiber comprising a cross-linkable protein polymer and a transglutaminase. A method for producing a nanofiber, the method comprising: combining a first solution comprising a cross-linkable protein polymer and a second solution comprising a transglutaminase to produce a liquid electro spinning mixture (LEM) characterized by an environment that is unsuitable for the transglutaminase to be enzymatically active on the cross-linkable protein polymer; and electro spinning the LEM to form a nanofiber comprising the TGase and the cross-linkable protein polymer.

A nanofiber comprising a cross-linkable protein polymer and a transglutaminase. A method for producing a nanofiber, the method comprising: combining a first solution comprising a cross-linkable protein polymer and a second solution comprising a transglutaminase to produce a liquid electro spinning mixture (LEM) characterized by an environment that is unsuitable for the transglutaminase to be enzymatically active on the cross-linkable protein polymer; and electro spinning the LEM to form a nanofiber comprising the TGase and the cross-linkable protein polymer.