A patch for treating vascular ulcers caused by excessive enzymatic activity may include a substrate configured to span a vascular ulcer as well as a linking material that is disposed relative to the substrate and has an affinity for an enzyme involved in causing the vascular ulcer. A magnetic material may be coupled to the linking material. In some cases, the enzymes involved in causing the vascular ulcer may become coupled to the linking material and thus become coupled to the magnetic material so that that the enzymes can be removed by applying a magnetic field in the proximity of the vascular ulcer. The enzymes may include matrix metalloproteinases.

The present invention relates to plasma-based films and in particular to flexible plasma-based films. The invention further relates to and to methods of making and using the flexible plasma-based films. Embodiments of the invention have been particularly developed for making flexible plasma-based films useful as a hemostat in the treatment and/or prevention of mild to severe as well as arterial bleedings, as an anti-adhesive sheet to reduce or prevent development of surgery-induced adhesions, as a wound healing patch, as a wound dressing, or as a film useful in hernia repair. Embodiments of the invention will be described hereinafter with reference to these applications. However, it will be appreciated that the invention is not limited to this particular field of use.

A method of sealing a durotomy from which cerebrospinal fluid is leaking. A durotomy sealant dressing is prepared by applying an active agent to a dextran base. The durotomy sealant dressing is applied to a durotomy. At least a portion of the durotomy sealant dressing dissolves. The durotomy is sealed with the dissolved durotomy sealant dressing to substantially prevent cerebrospinal fluid from flowing through the durotomy.

A method of sealing a durotomy from which cerebrospinal fluid is leaking. A durotomy sealant dressing is prepared by applying an active agent to a dextran base. The durotomy sealant dressing is applied to a durotomy. At least a portion of the durotomy sealant dressing dissolves. The durotomy is sealed with the dissolved durotomy sealant dressing to substantially prevent cerebrospinal fluid from flowing through the durotomy.

The present invention relates to a compression bandage for treating wounds comprised of a linear elastic compression wrap and a sterilized polymer foam layer containing a plurality of antimicrobial dyes with at least one dye being gram positive and at least one other dye being gram negative and a biofilm reduction agent and wherein said foam is secured to said linear elastic compression wrap.

The present invention relates to a compression bandage for treating wounds comprised of a linear elastic compression wrap and a sterilized polymer foam layer containing a plurality of antimicrobial dyes with at least one dye being gram positive and at least one other dye being gram negative and a biofilm reduction agent and wherein said foam is secured to said linear elastic compression wrap.

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions for forming such fibers are also described, as is the use of the fibers, wound dressings and compositions.

Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions for forming such fibers are also described, as is the use of the fibers, wound dressings and compositions.

An enzyme-degradable system for undergarments and feminine hygiene articles works to decompose the undergarments and feminine hygiene articles upon being triggered by bodily fluids, such as urine. The undergarment or feminine hygiene article comprises an absorbent core, an inner sheet of biodegradable material, and an outer sheet of biodegradable material. The core includes at least one of the following: a cellulose material, a wood pulp, a biodegradable and bioactive thermoplastic aliphatic polyester derived from renewable resources (polylactic acid plasticPLA), and a superabsorbent polymer (SAP). The inner and outer sheets comprise a plant based cellulosic nonwoven material. The cellulase enzyme decomposes the absorbent core, the inner sheet, and the outer sheet upon contact with a bodily fluid. The cellulase enzyme may include DIS-1018 Cellulose-AN, a pH buffer, and additives. Fasteners made from a resilient, biodegradable material help secure the undergarments and feminine hygiene articles to the body.

An enzyme-degradable system for undergarments and feminine hygiene articles works to decompose the undergarments and feminine hygiene articles upon being triggered by bodily fluids, such as urine. The undergarment or feminine hygiene article comprises an absorbent core, an inner sheet of biodegradable material, and an outer sheet of biodegradable material. The core includes at least one of the following: a cellulose material, a wood pulp, a biodegradable and bioactive thermoplastic aliphatic polyester derived from renewable resources (polylactic acid plasticPLA), and a superabsorbent polymer (SAP). The inner and outer sheets comprise a plant based cellulosic nonwoven material. The cellulase enzyme decomposes the absorbent core, the inner sheet, and the outer sheet upon contact with a bodily fluid. The cellulase enzyme may include DIS-1018 Cellulose-AN, a pH buffer, and additives. Fasteners made from a resilient, biodegradable material help secure the undergarments and feminine hygiene articles to the body.