The present invention is directed to a hemostatic patch comprising a porous substrate and at least a pair of co-reactive polymer reagents comprising at least one nucleophilic polyalkylene oxide based component and at least one electrophilic polyalkylene oxide-based on the porous substrate in a molar ratio of about 0.2 to about 0.9:1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to processes for the manufacture and use of such hemostatic patches.

Disclosed is a particulate water-absorbent resin composition containing at least one selected from the group consisting of a microporous inorganic material, silver, and a silver compound, and a polymer particle, in which the polymer particle contains an inorganic reducing agent.

A compound made by copolymerizing a poly(N-isopropylacrylamide) chain transfer agent, an acrylate salt, and a polyethylene glycol diacrylate. A compound made by copolymerizing a polyethylene glycol, a glycerol ethoxylate, and an aliphatic diisocyanate.

There are provided herein bioadhesive compositions which include at least one catechol derivatives, such as, caffeic acid derivatives, and at least one synthetic thermoplastic polymer, wherein exposure to heat causes the bioadhesive composition to transform into a non-solid state and to cohesively adhere to a biological tissue upon subsequent cooling. Further provided are methods of making the compositions and uses thereof in repairing tissue damage, such as, for example, in hernia repair surgeries.

Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.

Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.

A wound dressing is provided. The wound dressing includes a moisture-transmissible backing layer having a first major surface, a second major surface, and a backing layer perimeter; an absorbent hydrophilic adhesive adhered to at least a portion of the second major surface of the backing layer, the absorbent hydrophilic adhesive comprising an absorbent hydrophilic adhesive perimeter; an antimicrobial agent disposed in the absorbent hydrophilic adhesive; a porous layer having a first side adhered to the absorbent hydrophilic adhesive, a second side, and a porous layer perimeter; and a second hydrophobic adhesive adhered to the second side of the porous layer. The second major surface has a first hydrophobic adhesive disposed thereon proximate the backing layer perimeter. 100% of the absorbent hydrophilic adhesive perimeter is overlapped by the backing layer. At least 50% of the porous layer perimeter is overlapped by the absorbent hydrophilic adhesive.

A skin-friendly absorbent structure providing oxygen, comprising a absorbing layer and skin-friendly and oxygen-providing units, the skin-friendly and oxygen-providing unit being evenly dispersed in partial or entire scope of the absorbing layer wherein the skin-friendly and oxygen-providing unit comprises oxygen providing units and pH regulating units; and the pH of the skin-friendly absorbent structure is between 4 and 7 after absorbing liquids.

A skin-friendly absorbent structure providing oxygen, comprising a absorbing layer and skin-friendly and oxygen-providing units, the skin-friendly and oxygen-providing unit being evenly dispersed in partial or entire scope of the absorbing layer wherein the skin-friendly and oxygen-providing unit comprises oxygen providing units and pH regulating units; and the pH of the skin-friendly absorbent structure is between 4 and 7 after absorbing liquids.

A fiber having a surface region and an interior region includes a polymer comprising at least one of a vinyl acetate moiety or a vinyl alcohol moiety, the fiber having a transverse cross-section including the interior region comprising the polymer having a first degree of hydrolysis and the surface region comprising the polymer having a second degree of hydrolysis greater than the first degree of hydrolysis.