A method for manufacturing a wound dressing having a substrate, and a wound dressing manufactured by such a method are described. The method has a step of providing a sacrificial layer of material to be perforated by means of a hot pin perforator, in order to remove any molten residues on the heated pins of the hot pin perforator, before the same pins are used to make holes in the substrate. The presented method is cost effective, robust and reduces the risk of contaminating substances being embedded in the substrate during the hole making process.

The wound therapy apparatus may include a wound interface sealingly securable to the skin surface around a wound bed to encloses the wound bed within an enclosed space that is fluid-tight. The wound interface may be sufficiently deformation resistant to distend at least a portion of the wound bed into the enclosed space when pressure p.sub.0 within the enclosed space is less than ambient pressure p.sub.amb. Fluid may be communicated with the enclosed space when the wound interface is sealingly secured to the skin surface in order to vary a pressure p.sub.0 within the enclosed space periodically over the pressure range p.sub.min≤p.sub.0≤p.sub.max. The variation of the pressure p.sub.0 may distend the wound bed into communication with a pad received within the enclosed space and decreases the wound bed contact with the pad. Related methods of use of the wound therapy apparatus are also disclosed.

The wound therapy apparatus may include a wound interface sealingly securable to the skin surface around a wound bed to encloses the wound bed within an enclosed space that is fluid-tight. The wound interface may be sufficiently deformation resistant to distend at least a portion of the wound bed into the enclosed space when pressure p.sub.0 within the enclosed space is less than ambient pressure p.sub.amb. Fluid may be communicated with the enclosed space when the wound interface is sealingly secured to the skin surface in order to vary a pressure p.sub.0 within the enclosed space periodically over the pressure range p.sub.min≤p.sub.0≤p.sub.max. The variation of the pressure p.sub.0 may distend the wound bed into communication with a pad received within the enclosed space and decreases the wound bed contact with the pad. Related methods of use of the wound therapy apparatus are also disclosed.

Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.

The invention is directed towards a device, method of using and making the same and more particularly to a sterile, biocompatible, fiber free, foam device configured to be used in various different uses, e.g., medical uses, make-up removal uses, and other uses.

A method of treating a fiber includes admixing a fiber comprising a polymer comprising at least one of a vinyl acetate moiety or a vinyl alcohol moiety and having a degree of hydrolysis less than 100% with a hydrolysis agent solution to form a mixture so as to increase the degree of hydrolysis of at least a portion of the fiber.

A self-sterilizing wound dressing is disclosed. The wound dressing comprises a substrate having a first surface facing at least a portion of a wound or a surgical site and a second surface facing opposite to the first surface. At least one surface of the substrate comprises a sulfonated polymer selected from the group of perfluorosulfonic acid polymers, polystyrene sulfonates, sulfonated block copolymers, sulfonated polyolefins, sulfonated polyimides, sulfonated polyamides, sulfonated polyesters, sulfonated polysulfones, sulfonated polyketones, sulfonated poly(arylene ether), and mixtures thereof. The sulfonated polymer is sufficiently or selectively sulfonated to contain from 10-100 mol % sulfonic acid or sulfonate salt functional groups based on the number of monomer units, for killing at least 90% of microbes in less than 120 minutes of coming into contact with the wound dressing.

A self-sterilizing wound dressing is disclosed. The wound dressing comprises a substrate having a first surface facing at least a portion of a wound or a surgical site and a second surface facing opposite to the first surface. At least one surface of the substrate comprises a sulfonated polymer selected from the group of perfluorosulfonic acid polymers, polystyrene sulfonates, sulfonated block copolymers, sulfonated polyolefins, sulfonated polyimides, sulfonated polyamides, sulfonated polyesters, sulfonated polysulfones, sulfonated polyketones, sulfonated poly(arylene ether), and mixtures thereof. The sulfonated polymer is sufficiently or selectively sulfonated to contain from 10-100 mol % sulfonic acid or sulfonate salt functional groups based on the number of monomer units, for killing at least 90% of microbes in less than 120 minutes of coming into contact with the wound dressing.

The present invention relates to foam. In particular, the present invention relates to profiled foams and processes for profiling absorbent foam products. More particularly, the present invention relates to processes for producing a profiled absorbent polyurethane foam product, comprising the steps of foaming, curing, profiling and drying, wherein profiling occurs before drying; and absorbent aliphatic polyurethane foam products having at least one profiled surface.

Disclosed methods include formulating azobenzene-based polymer networks to induce a modulus change in a highly crosslinked polymer, in vivo, with no external heat requirement and using a benign light as the source of stimuli. A modulus change can be achieved via a coating on the substrate and within the bulk of the substrate via photoexposure. The azobenzene-based polymer network can be formed as a coating or in the bulk of a material from either a glassy composition comprising methyl methacrylate (MMA), poly (methyl methacrylate) (PMMA), and triethylene glycol dimethacrylate (TEGDMA) or a soft material comprising of long-chain difunctional acrylates. The disclosed technology also includes methods of biofilm disruption and removal from the surface of a substrate, and includes methods of inhibiting biofilm growth and cell attachment to a substrate.