Wound dressings comprising absorbable polyelectrolyte material and ionic crystals and methods of making the same are provided. The weight percent of ionic crystals in the polyelectrolyte materials can be adjusted for desired uses of the wound dressings.

A method for promoting spine fusion inside intersomatic cages, comprising placing a fusion cage between two vertebral bodies, and injecting a bone cement paste inside said fusion cage, said bone cement paste containing a powder component comprising α-tricalcium phosphate (α-TCP) particles having an average size greater than or equal to 9 μm, and a liquid component comprising blood.

The present disclosure relates to a hydrogel comprising hyaluronic acid modified by serotonin, a use thereof, and a method of preparing the same.

The present disclosure pertains to the field of biomedical materials, and in particular relates to a medical hydrogel, a preparation method and uses thereof, and a kit for preparing the medical hydrogel. The medical hydrogel of the present disclosure comprises a hydrogel skeleton, and a chelating agent chelated to the hydrogel skeleton; wherein the hydrogel skeleton comprises a polymer that is formed by the bonding of a polyethylene glycol derivative I having a structure shown in Formula (I) and a polyethylene glycol derivative II having a structure shown in Formula (II) and has multiple “long arms”. After tannic acid and/or citric acid as a chelating agent chelates with the hydrogel skeleton, a medical hydrogel can be obtained, which has good bacteriostatic properties, mechanical properties, adhesion properties, low swelling properties, and controllable gel formation rate and degradation rate. Moreover, the hydrogel is able to maintain viscosity in a wet state without being affected by body fluids, and it can still ensure effective adhesion and closure of wounds if there is movement or pulsation of the tissue, thus having great clinical application prospects.

Some tissue adhesives include a solid having bio-absorbable fibers and at least one of nano-spheres, micro-spheres, nano-tubules, or micro-tubules. A first layer of the solid has a positive Poisson's ratio and a second layer of the solid has a negative Poisson's ratio. In some cases, the second layer has been transformed from a positive Poisson's ratio material to a negative Poisson's ratio material. In some cases, an entire face of the first layer is in contact with an entire face of the second layer. In some cases, the second layer includes one or more pores, at least a portion of the one or more pores containing a secretion from one or more barnacles. In some cases, the secretion is configured to adhere the tissue adhesive to one or more layers of tissue to at least partially close a wound.

The invention provides a method for preparing tissue-adhesive sheets that may suitably be applied as an implantable haemostatic or sealing construct during surgical procedures, said method comprising: providing a fibrous sheet comprising a three-dimensional interconnected interstitial space; providing reactive polymer particles comprising a water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups in blood under the formation of a covalent bond; placing the fibrous sheet and the reactive polymer particles between two electrodes; simultaneously subjecting the fibrous sheet and the reactive polymer particles to an electric field of 0.1 to 40 kV/mm to impregnate the interconnected interstitial space of the fibrous sheet with the reactive polymer particles.

The invention relates to a biocompatible, flexible, haemostatic sheet comprising: a water-resistant cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space, said fibrous carrier structure comprising fibres containing a nucleophilic polymer carrying reactive nucleophilic groups; and distributed within the interstitial space, a plurality of reactive polymer particles comprising a water-soluble electrophilic polymer carrying at least three reactive electrophilic groups that are capable of reacting with amine groups in tissue and blood, as well as with reactive nucleophilic groups of the nucleophilic polymer, under the formation of a covalent bond, said reactive polymer particles having a diameter in the range of 0.5-100 μm and being present in an amount of at least 3% by weight of the fibrous carrier structure.

When blood is absorbed by the haemostatic sheet of the present invention, the reactive polymer particles within the sheet start dissolving as soon as they are ‘wetted’ by the blood, thereby allowing the electrophilic polymer to react with both reactive nucleophilic groups in the blood and tissue and reactive nucleophilic groups in the fibrous carrier structure, thereby inducing blood coagulation and tissue sealing, both of which contribute to haemostasis.

A pulverulent semisynthetic material, derived from a natural marine biomaterial, namely the aragonitic inner layer of the shell of bivalve molluscs selected from Pinctadines, notably Pinctada maxima, margaritifera, and Tridacnes, notably Tridacna gigas, maxima, derasa, tevaroa, squamosa, crocea, Hippopus hippopus, Hippopus porcelanus, in pulverulent form, with the addition of insoluble and soluble biopolymers and calcium carbonate transformed by carbonation.

Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

The present invention relates to microparticles that can be used as drug-loaded hydrogel particles for embolization and a method for manufacturing same. The microparticles of the present invention have a very excellent anticancer agent adsorption ability, a short anticancer agent adsorption time, and a controllable decomposition time when administered in vivo. Therefore, when the microparticles of the present invention are used in chemoembolization, not only the anticancer effect is excellent, but also side effects can be minimized.