The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

There are provided herein bioadhesive compositions which include at least one catechol derivatives, such as, caffeic acid derivatives, and at least one synthetic thermoplastic polymer, wherein exposure to heat causes the bioadhesive composition to transform into a non-solid state and to cohesively adhere to a biological tissue upon subsequent cooling. Further provided are methods of making the compositions and uses thereof in repairing tissue damage, such as, for example, in hernia repair surgeries.

There are provided herein bioadhesive compositions which include at least one catechol derivatives, such as, caffeic acid derivatives, and at least one synthetic thermoplastic polymer, wherein exposure to heat causes the bioadhesive composition to transform into a non-solid state and to cohesively adhere to a biological tissue upon subsequent cooling. Further provided are methods of making the compositions and uses thereof in repairing tissue damage, such as, for example, in hernia repair surgeries.

Delivery systems, compositions, and methods for forming and delivering biomaterials from two components are described. Specifically, a composition includes a first component and a second component that are each formulated to be crosslinked with the other to form a hydrogel. The first component and the second component are formulated to have an initial storage modulus (initial G) and an initial loss modulus (initial G″) when initially combined such that a ratio of the initial G″ to the initial G is between about 5 and about 100. The first component and the second component are formulated to have a gelation storage modulus (gelation G) and a gelation loss modulus (gelation G″) at a gelation time after the first component and the second component are combined such that a atio of the gelation G″ to the gelation G is less than about 1. The gelation time is less than about 120 seconds.

Delivery systems, compositions, and methods for forming and delivering biomaterials from two components are described. Specifically, a composition includes a first component and a second component that are each formulated to be crosslinked with the other to form a hydrogel. The first component and the second component are formulated to have an initial storage modulus (initial G) and an initial loss modulus (initial G″) when initially combined such that a ratio of the initial G″ to the initial G is between about 5 and about 100. The first component and the second component are formulated to have a gelation storage modulus (gelation G) and a gelation loss modulus (gelation G″) at a gelation time after the first component and the second component are combined such that a atio of the gelation G″ to the gelation G is less than about 1. The gelation time is less than about 120 seconds.

An adhesive applicator (1) comprises a receiver (3) having a tubular body with a closed first end (13) and an opposed second end (15), the tubular body having a deformable wall (11), an adhesive composition contained within the tubular body, and an applicator tip (5) mounted on the tubular body and comprising a foam material (7) having an applicator (7a-7c) external of the applicator (1) for applying said adhesive, the applicator being such that deformation of the tubular body causes the adhesive to be expressed through the applicator tip (5), The foam material is a reticulated foam felt (7) and allows for relatively constant flow of the adhesive through the foam felt and to the applicator surface thereof over a wide range of viscosity conditions of the adhesive and pressure applied to the deformable body of the applicator (1).

An adhesive applicator (1) comprises a receiver (3) having a tubular body with a closed first end (13) and an opposed second end (15), the tubular body having a deformable wall (11), an adhesive composition contained within the tubular body, and an applicator tip (5) mounted on the tubular body and comprising a foam material (7) having an applicator (7a-7c) external of the applicator (1) for applying said adhesive, the applicator being such that deformation of the tubular body causes the adhesive to be expressed through the applicator tip (5), The foam material is a reticulated foam felt (7) and allows for relatively constant flow of the adhesive through the foam felt and to the applicator surface thereof over a wide range of viscosity conditions of the adhesive and pressure applied to the deformable body of the applicator (1).

A crosslinkable composition is useful for preparing a skin contact adhesive or a coating on a substrate. The crosslinkable composition includes (A) a polyurethane-polyorganosiloxane copolymer and (B) a curing catalyst. The skin contact adhesive prepared by crosslinking the crosslinkable composition is useful in applications such as adhesives for medical tapes, adhesives for wound dressings, adhesives for prosthetics, ostomy appliance adhesives, adhesives for medical monitoring appliances, adhesives for scar therapy treatments, adhesives for cosmetic patches, and transdermal drug delivery systems.

A method is provided for producing an adhesive material (1) for a medical application such as a dressing. The method includes at least one step for coating a first surface (2b) of any substrate (4), called receiving substrate, using a layer of previously coated silicone on an anti-adherent liner (3). The silicone layer is an adhesive gel (2). The method further includes, prior to the coating step, a corona treatment step for the surface of the adhesive silicone gel that is intended to coat the receiving substrate (4).

A method is provided for producing an adhesive material (1) for a medical application such as a dressing. The method includes at least one step for coating a first surface (2b) of any substrate (4), called receiving substrate, using a layer of previously coated silicone on an anti-adherent liner (3). The silicone layer is an adhesive gel (2). The method further includes, prior to the coating step, a corona treatment step for the surface of the adhesive silicone gel that is intended to coat the receiving substrate (4).