An implant includes a section made of polymer, wherein at least a portion of the section has a layer of a polymerizable and/or cross-linkable material. A method for fixation of a bone plate having several plate holes using the implant includes removing a cover sheet protecting the layer of polymerizable and/or cross-linkable material, activating the layer of polymerizable and/or cross-linkable material with electromagnetic energy or with moisture, introducing the implant into one of the plate holes of the bone plate when the bone plate is positioned on a bone, pressing on an end of the implant in order to contact the activated layer of polymerizable and/or cross-linkable material with the bone underneath the bone plate, and allowing the activated and pressurized layer of polymerizable and/or cross-linkable material to polymerize and/or cross-link and to adhere to the bone.

A composition with improved adhesive and sealant properties comprising a) a pre-polymer comprising a polymeric unit of the general formula (-A-B-).sub.n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1, and b) an anhydride compound.

A composition with improved adhesive and sealant properties comprising a) a pre-polymer comprising a polymeric unit of the general formula (-A-B-).sub.n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1, and b) an anhydride compound.

Described herein are polymers and associated methods to occlude structures and malformations of the vasculature with polymers with delayed controlled rates of expansion. Methods of forming such devices are also disclosed.

Described herein are polymers and associated methods to occlude structures and malformations of the vasculature with polymers with delayed controlled rates of expansion. Methods of forming such devices are also disclosed.

The present invention relates to a composition for hydrogel formation, a hydrogel formed by photo-crosslinking same, and a method for preparing the hydrogel and, more specifically, to a composition which comprises a photo-initiator and a polyglutamic acid polymer having a photo-crosslinkable functional group introduced thereto and is capable of forming a hydrogel in real time through photo-crosslinking, to a hydrogel which is formed by photo-crosslinking the composition and can be utilized as a tissue adhesive, a surgical sealant, anti-adhesive agent, or the like due to excellent biocompatibility, superior adhesive strength in wet environments, flexibility, and ease of use, and to a method for preparing the hydrogel.

The present invention relates to a composition for hydrogel formation, a hydrogel formed by photo-crosslinking same, and a method for preparing the hydrogel and, more specifically, to a composition which comprises a photo-initiator and a polyglutamic acid polymer having a photo-crosslinkable functional group introduced thereto and is capable of forming a hydrogel in real time through photo-crosslinking, to a hydrogel which is formed by photo-crosslinking the composition and can be utilized as a tissue adhesive, a surgical sealant, anti-adhesive agent, or the like due to excellent biocompatibility, superior adhesive strength in wet environments, flexibility, and ease of use, and to a method for preparing the hydrogel.

According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of: temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein: the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety; the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of: temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein: the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety; the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

A skin compatible component attachable to mammalian skin. The component is formed as a silicone matrix comprising a polyorganosiloxane derived silicone polymer and a moisture control particulate and permeability modifying polymer distributed within the polymer network. The skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peri-stomal skin.