Various adhesive compositions are described which may optionally comprise one or more active agents such as pharmaceutical agents. The incorporation of one or more absorbents in combination with one or more crystallization inhibitors improves adhesive characteristics of the compositions. Also described are related methods of improving adhesive characteristics of adhesive compositions with the use of a combination of absorbent and inhibitor. Also described are related methods of using the compositions and articles incorporating such compositions.

Various adhesive compositions are described which may optionally comprise one or more active agents such as pharmaceutical agents. The incorporation of one or more absorbents in combination with one or more crystallization inhibitors improves adhesive characteristics of the compositions. Also described are related methods of improving adhesive characteristics of adhesive compositions with the use of a combination of absorbent and inhibitor. Also described are related methods of using the compositions and articles incorporating such compositions.

Various compositions of matter, methods of making compositions of matter, and methods of using compositions of matter, e.g. for inducing hemostasis, are disclosed. In some embodiments, a starting fibrin material is subjected to controlled hydrolysis, desirably base-catalyzed, to prepare a fibrin hydrolysate material with increased water sorption capacity. Such fibrin hydrolysate materials, alone or combined with one or more additional substances, can be used in the preparation of hemostasis promoting foams, powders or gels. In some embodiments, a starting dialdehyde starch material is subjected to controlled hydrolysis to prepare a dialdehyde starch hydrolysate material. Such dialdehyde starch hydrolysate materials, alone or combined with one or more additional substances, in some cases combined with a fibrin hydrolysate material, can be used in the preparation of hemostasis promoting foams, powders or gels.

Various compositions of matter, methods of making compositions of matter, and methods of using compositions of matter, e.g. for inducing hemostasis, are disclosed. In some embodiments, a starting fibrin material is subjected to controlled hydrolysis, desirably base-catalyzed, to prepare a fibrin hydrolysate material with increased water sorption capacity. Such fibrin hydrolysate materials, alone or combined with one or more additional substances, can be used in the preparation of hemostasis promoting foams, powders or gels. In some embodiments, a starting dialdehyde starch material is subjected to controlled hydrolysis to prepare a dialdehyde starch hydrolysate material. Such dialdehyde starch hydrolysate materials, alone or combined with one or more additional substances, in some cases combined with a fibrin hydrolysate material, can be used in the preparation of hemostasis promoting foams, powders or gels.

The present disclosure discloses a starch-based fluffy particle, a preparation method and use thereof. The preparation method of the starch-based fluffy particle comprises the following steps of: (1) adding water into starch or modified starch for gelatinization to obtain a starch paste; (2) adding the starch paste into a polar organic solvent, stirring, standing and centrifuging to collecting a precipitate; and (3) freeze-drying, crushing and sieving the precipitate in sequence to prepare the starch-based fluffy particle. The starch-based fluffy particles are porous and fluffy with a large pore size, have excellent water absorption speed, water absorption rate and degradation rate, and can achieve the purpose of rapid and efficient hemostasis. Moreover, the starch-based fluffy particles are free of dispersing agent, emulsifying agent or cross-linking agent, have the characteristics of safety and reliability, and can meet the hemostatic requirement of in-vivo environment.

The present disclosure discloses a starch-based fluffy particle, a preparation method and use thereof. The preparation method of the starch-based fluffy particle comprises the following steps of: (1) adding water into starch or modified starch for gelatinization to obtain a starch paste; (2) adding the starch paste into a polar organic solvent, stirring, standing and centrifuging to collecting a precipitate; and (3) freeze-drying, crushing and sieving the precipitate in sequence to prepare the starch-based fluffy particle. The starch-based fluffy particles are porous and fluffy with a large pore size, have excellent water absorption speed, water absorption rate and degradation rate, and can achieve the purpose of rapid and efficient hemostasis. Moreover, the starch-based fluffy particles are free of dispersing agent, emulsifying agent or cross-linking agent, have the characteristics of safety and reliability, and can meet the hemostatic requirement of in-vivo environment.

The present disclosure discloses a starch-based fluffy particle, a preparation method and use thereof. The preparation method of the starch-based fluffy particle comprises the following steps of: (1) adding water into starch or modified starch for gelatinization to obtain a starch paste; (2) adding the starch paste into a polar organic solvent, stirring, standing and centrifuging to collecting a precipitate; and (3) freeze-drying, crushing and sieving the precipitate in sequence to prepare the starch-based fluffy particle. The starch-based fluffy particles are porous and fluffy with a large pore size, have excellent water absorption speed, water absorption rate and degradation rate, and can achieve the purpose of rapid and efficient hemostasis. Moreover, the starch-based fluffy particles are free of dispersing agent, emulsifying agent or cross-linking agent, have the characteristics of safety and reliability, and can meet the hemostatic requirement of in-vivo environment.

The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.

The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.

The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.