An hydrogel comprising chitosan and two weak bases having different pKb values. In some embodiments, one of the weak bases if sodium hydrogen carbonate (SHC). Also, use of the hydrogel in medical and cosmetic treatments.

The hemostatic material composition contains a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure and contains a hydrophobic solvent.

The hemostatic material composition contains a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure and contains a hydrophobic solvent.

The hemostatic material composition contains a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure, a hydrophobic solvent, and a crosslinked particle containing one or more compounds selected from the group consisting of a crosslinked protein and a crosslinked polysaccharide.

The hemostatic material composition contains a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure, a hydrophobic solvent, and a crosslinked particle containing one or more compounds selected from the group consisting of a crosslinked protein and a crosslinked polysaccharide.

Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.

Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.

Proposed is a hemostatic sprayer for stopping a flow of blood from a bleeding portion of the human body, the hemostatic sprayer including a powder casing inside which an accommodation space is formed and which includes inlet and outlet ports, hemostatic in the form of powders being pre-stored in the accommodation space, and the inlet and outlet ports connecting thereto, and a receptacle inside which gas is compressed and pre-stored and which has a supply port on one side, the supply port separably connecting to the inlet port, wherein the supply port is open as a result of pressing by the powder casing, wherein, through the open supply port, the gas is supplied with a preset pressure toward the inlet port and flows into the accommodation space through the inlet port, and wherein the gas flowing is discharged together with the hemostatic through the outlet port while scattering the hemostatic.

Proposed is a hemostatic sprayer for stopping a flow of blood from a bleeding portion of the human body, the hemostatic sprayer including a powder casing inside which an accommodation space is formed and which includes inlet and outlet ports, hemostatic in the form of powders being pre-stored in the accommodation space, and the inlet and outlet ports connecting thereto, and a receptacle inside which gas is compressed and pre-stored and which has a supply port on one side, the supply port separably connecting to the inlet port, wherein the supply port is open as a result of pressing by the powder casing, wherein, through the open supply port, the gas is supplied with a preset pressure toward the inlet port and flows into the accommodation space through the inlet port, and wherein the gas flowing is discharged together with the hemostatic through the outlet port while scattering the hemostatic.

The present invention relates to novel formulations comprising a sprayable composition comprising tranexamic acid and chitosan for use in the treatment of wounds or injuries, in particular for use as a topical hemostatic composition or for surgical intervention and the process for preparation thereof.