Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.

Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stem cells for treating fistulae.

A therapeutic composition can include an amount of amniotic fluid having a therapeutically effective amount of at least one protein, hyaluronic acid, or both. The therapeutic composition can be substantially free of lanugo, vernix, and cells harvested with the amniotic fluid.

A therapeutic composition can include an amount of amniotic fluid having a therapeutically effective amount of at least one protein, hyaluronic acid, or both. The therapeutic composition can be substantially free of lanugo, vernix, and cells harvested with the amniotic fluid.

The present disclosure concerns a mineralized tissue adhesive or filler composition comprising an intermolecular crosslinked osteopontin protein for treating an exposed surface of a mineralized tissue. The mineralized tissue adhesive or filler composition can be added directly on the exposed surface of the mineralized tissue or on a layer of monodisperse OPN protein which has been deposited on the exposed surface of the mineralized tissue. The present disclosure also includes methods and kits of using the mineralized tissue adhesive or filler composition especially in dental applications. The present application also provides dental coatings, fillings, bondings and veneers comprising the mineralized tissue adhesive or filler composition described herein.

A method of inhibiting bleeding from an open surgical site includes mixing (i) a flowable gel solution comprising a biopolymer dissolved in a first solvent and (ii) a flowable hardener solution comprising a cross-linking agent dissolved in a second solvent to form a flowable hemostatic gel composition. The method also includes applying the flowable hemostatic gel composition to the open surgical site. The cross-linking agent links chains of the biopolymer together to form a solid hydrogel that inhibits bleeding from the surgical site.

This invention provides preparations, compositions, products, and applications of photo-crosslinked hydrogels. Component Aa photosensitive polymer derivative, component Bthe photoinitiator, and auxiliary component Cother biocompatible polymer derivative each are respectively dissolved in a biocompatible medium to obtain solution A, solution B, and solution C. The solution A, the solution B, and the optional solution C are mixed homogenously to obtain a hydrogel precursor solution. The hydrogel precursor solution is subject to irradiation of the UV light for photocoupled crosslinking to form a photo-crosslinked hydrogel. The photo-crosslinked hydrogel exhibit rapid speed of photo-curing, strong tissue adhesion, excellent mechanical properties, good biocompatibility, and excellent clinical operability. In addition, this invention also provides a kit for making the photo-crosslinked hydrogel, and applications thereof in tissue engineering, regenerative medicine, 3D printing, and as a carrier of cell, protein, or drug.

The present invention relates to protein biocoacervates and biomaterials vessel graft systems used in cardiovascular applications and other medical applications, the components utilized in the vessel graft systems and the methods of making and using such systems. More specifically the present invention relates to protein biocoacervates and biomaterials vessel graft systems used in various medical applications and/or the devices used in such vessel graft systems including, but not limited to, vessel grafts as drug delivery devices for the controlled release of pharmacologically active agents, tubular grafts, vascular grafts, protein biomaterial sutures and biomeshes, protein biomaterial adhesives and glues, and other biocompatible biocoacervate or biomaterial devices used in the vessel graft systems of the present invention.

Disclosed is an adhesive composition, devices including the adhesive composition and uses of the devices including the adhesive composition. The adhesive composition is for attachment to skin and includes an adhesive polymer component selected from a mixture of a polyethylene copolymer and polypropylene glycol (PPG), and styrene-ethylene/butylene-styrene (SEBS) block copolymer. The composition further includes polyolefin, polybutene, polyacrylic acid (PAA), and at least one further absorbent material.

Disclosed is an adhesive composition, devices including the adhesive composition and uses of the devices including the adhesive composition. The adhesive composition is for attachment to skin and includes an adhesive polymer component selected from a mixture of a polyethylene copolymer and polypropylene glycol (PPG), and styrene-ethylene/butylene-styrene (SEBS) block copolymer. The composition further includes polyolefin, polybutene, polyacrylic acid (PAA), and at least one further absorbent material.