The present invention relates to hydrogels prepared using silylated organic molecules (such as silylated biomolecules), a process for obtaining the same, and uses thereof.

The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation N.sup.α C8-C6 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.

The present disclosure relates to birch bark extracts, methods of producing such extracts, stable pharmaceutical compositions containing such extracts and methods of using of such extracts. The birch bark extracts of the present disclosure contain triterpenes, which are known to improve wound healing.

Disclosed herein are topical compositions for treating wounds. The topically compositions include a Serp-1 polypeptide or a nucleic acid encoding a Serp-1 polypeptide. Also disclosed are methods of treating a wound in subject. The methods include administering a topical formulation that includes a Serp-1 polypeptide or a nucleic acid encoding a Serp-1 polypeptide to the wound.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

A composition to treat epidermal insults may have an ungraphenated detonation synthesis nanodiamonds (UDSND) and medical grade Siberian Sea Buckthorn Berry Oil (SBB) composition in a blended uniform composition with 1% hydrocortisone cream; wherein the UDSND are at 2 nm to 4 nm in initial crystal size and in the range of 0.2% to 0.5% of the UDSND-SBB composition weight and the SBB which is 99.5% to 99.8% of the UDSND-SBB composition weight; and wherein total composition ratio is in the range of about 3:1 to 10:1 hydrocortisone cream to UDSND-SBB composition. Preferably, the total composition ratio can be about 6:1 hydrocortisone cream to UDSND-SBB composition.

The present disclosure describes compositions and methods to promote wound healing. The compositions and methods include an interleukin-1 beta (IL-1β) receptor antagonist (IL-1Ra), such as anakinra. The IL-1Ra can be administered topically to a chronic wound including a diabetic ulcer.

The invention relates to the use of microparticles in a self-adhesive silicone gel to increase adhesion. The invention relates to a self-adhesive silicone gel that comprises microparticles and has improved adhesion properties, in particular when same also comprises additional chemical compounds/derivatives, more particularly compounds that are active, soluble or miscible in the silicone gel.

Provided are a superabsorbent polymer capable of exhibiting improved bacterial growth-inhibitory property without deterioration in physical properties of the superabsorbent polymer, such as water retention capacity and absorbency under pressure, or without an increase in the generation of dust, and a preparation method thereof. The superabsorbent polymer may include a base polymer powder including a crosslinked polymer of water-soluble ethylenically unsaturated monomers including acidic groups, of which at least a part is neutralized; and a surface-crosslinked layer which is obtained by additionally crosslinking the crosslinked polymer via a surface crosslinking agent to be formed on the surface of the base polymer powder, wherein the crosslinked polymer of the base polymer powder or the surface-crosslinked layer includes an antimicrobial agent including an organic acid salt having an aromatic ring inside the crosslinked structure thereof.