Disclosed in the present invention are a preparation method for and a use method of a collagen microfiber hemostatic material. Collagen microfibers are obtained by performing high-speed shearing on a solid collagen material, after the collagen microfibers are dispersed in an aqueous phase, a procoagulant active ingredient modifies the surfaces of the collagen microfibers by means of linking molecules; and a collagen microfiber hemostatic material is obtained by performing high-speed shearing again after freeze drying. The collagen microfiber material can be prepared simply and efficiently by means of high-speed shearing; the biological activity of the collagen material is maintained as much as possible; and the microfibers have a length range of 10-1000 μm and high dispersibility, thus facilitating spray processing. The procoagulant active ingredient can be efficiently and quantitatively loaded on the surfaces of the collagen microfibers by means of the linking molecules to enhance the hemostatic effect of the collagen microfibers. The collagen microfiber hemostatic material prepared in the present invention can be used for hemostasis of a bleeding wound by means of spraying application, thereby achieving the effect of non-contact fixed-point hemostasis.

A formulation for generating an adhesion barrier that includes a plurality of particles or a dry powder that is made of a polymer combination of at least one biodegradable polymer and at least one water soluble polymer is disclosed. Methods of making and delivering the formulation are further disclosed. The formulation of particles is deposited on a surface of internal body tissue and the deposited formulation absorbs moisture from the tissue and forms a film over the surface. The film acts as an adhesion barrier by reducing or preventing adhesion of the surface to other body tissue.

Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.

The present application relates to a film forming composition for application to mammalian skin, which composition comprises at least one polyurethane based polymer together with at least one acrylate based polymer. The film forming composition provides effective skin coating with good adhesion to the skin, and may be used as a skin protector or a wound dressing.

A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.

A fiber layer containing a fiber assembly and a liquid preparation for applying to a skin, the fiber layer being adjusted such that the basis weight of the fiber assembly and the permittivity of the liquid preparation are in a predetermined range, having controlled vapor permeability.

A coating film for human skin, the coating film comprising a fiber layer, wherein the fiber layer comprises: a fiber assembly in which fiber of a water-insoluble polymer with a fiber diameter of 50 nm or more and less than 10,000 nm is deposited; and a liquid preparation X present between fibers and on a surface of fibers in the fiber assembly, the fiber assembly has a basis weight Q of 0.08 to 1.0 mg/cm.sup.2, and the liquid preparation X has a basis weight P of 0.5 to 2.3 mg/cm.sup.2 and a relative permittivity of 1.0 to 27, and comprises a component (a): oil agent in a liquid state at 20° C. and has a relative permittivity of 0.5 to 20, and a component (b): polyol in a liquid state at 20° C. in which the content of the component (b) in the liquid preparation X is 50 mass % or less.

[Problem to be Solved] It is intended to provide a composition for hemostasis which can be uniformly applied to a bleeding site and exerts a high hemostatic effect.

[Solution] The present invention provides a composition to be applied as a spray to a subject, the spray being used for hemostasis, and the composition comprising a self-assembling peptide, wherein the self-assembling peptide self-assembles and thereby gels when the composition is applied to a bleeding site of the subject, and the self-assembling peptide is contained in the composition at a concentration at which the composition has an improved hemostatic ability as compared with that when directly applied.

Compositions and methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity.

Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.

A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial.