Provided are compositions and methods that involve viscoelastic poly(lactide-co-caprolactone) (PLCL) mixtures for use in wound healing. The PLCL mixtures provide an improved anti-fibrotic yet tissue-adhesive polymer sealant. The PLCL mixtures can be applied to a variety of wounds arising from surgical and non-surgical tissue damage.

The present invention relates to a biocompatible hydrogel comprising hyaluronic acid and polyethylene glycol, and more particularly, to a biocompatible hydrogel prepared by inducing inter-molecular and/or intra-molecular cross-linking of hyaluronic acid and polyethylene glycol only by irradiating radiation without adding a reactor, a chemical cross-linking agent, or the like, a method for preparing the same, and the use thereof.

According to some aspects of the invention a method for creation of a wound covering with haemostatic action includes: applying to an open wound a cell structure (grid)-forming water-soluble haemostatic composition designated as a Hemoblok consisting of a polyacrylic matrix as an active ingredient, where the matrix includes one or more polymeric carboxylic acid of a predetermined average molecular weight range, and a bactericidal agent; creating by Hemoblok on a wound surface a structure clot formation with blood plasma proteins, including albumin; creating by Hemoblok on the wound, a covering containing albumin molecules in cells of a polyacrylic structure matrix (grid), which is a primary organizer of sustainable grid structure clot film; further supplying of Hemoblok on an open wound surface to form a multilayered solid grid structure film; terminating of Hemoblok supply on a wound surface with following gradual replacement of a surface structure hemoblok-protein by fibrin.

A two-component system for the therapeutic treatment of skin lesions includes two components. A first component is an aqueous gel. A second component, called cross-linker, is an aqueous solution. The first component includes at least one biocompatible polymer, at least one polyacid or a salt thereof and characterized in that at least one preservative substance, at least one pharmacologically active substance can be present and in that the second component consists of a saline solution including calcium chloride, magnesium chloride and zinc chloride. A method of use involves the prior application of the first component, in the form of aqueous gel in a fluid-viscous state on the skin of a patient, then spraying with the second component as an aqueous solution, causing the formation in situ of a film of rubbery consistency and in that the rubbery film can be removed by washing the skin with water.

A composition for treating wounds is provided. The composition includes an antimicrobial component, an emulsifying agent, and a cidatrope component. The antimicrobial component can be selected from octenidine, poly(hexamethylene biguanide), a quaternary ammonium antimicrobial compound, and salts thereof. The cidatrope is not an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkalyl carboxylic acid, a phenolic compound, a (C1-C10)monohydric alkyl alcohol, or an ether glycol. In certain embodiments, the composition can be substantially free of water and C2-C5 lower alcohols. In certain embodiments, the composition further can comprise water. Methods of using the composition are also provided.

A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.

The present invention relates to a water resistant wound cover with high comfort and good air permeability. In particular, the present invention relates to an aqueous wound healing formulation comprising a water-soluble or a water-dispersible polymeric material that does not sting when applied to a minor injury to the skin.

The patent disclosure covers antibiofilm compositions, wound dressings, cleaning methods and treatment methods. The antibiofilm composition is comprised of between about 0.05% (w/w) to about 0.20% (w/w) benzalkonium chloride; between about 0.20% (w/w) to about 0.50% (w/w) 3-(tri-methoxysilyl)propyldimethyl octadecyl ammonium chloride; between about 0.25% (w/w) to about 0.75% (w/w) phenoxyethanol and between about 98.55% (w/w) to about 99.5% (w/w) deionized water. Disclosed are wound dressings having a reservoir of the antibiofilm composition. In the field of inanimate surfaces, disclosed are methods to clean and clean and protect inanimate surfaces. In the field of animate surfaces, disclosed are methods for the treatment of nose, ear and skin/facial disorders associated with biofilms.

Compositions and methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity.

A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.