The present invention relates to a nerve suture patch having a self-healing property, and a production method thereof, and more specifically, to a self-healing nerve suture patch containing a self-healing polymer and a hydrogel, and a production method thereof. The nerve suture patch may be rapidly attached to epineurium by the adhesiveness of the hydrogel and easily suture a damaged nerve.

Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.

There is provided a composition for forming an artificial skin that can shorten the cross-linking time while maintaining excellent application performance and coating performance.

A composition for forming an artificial skin of the present disclosure comprises a first agent and a second agent, wherein the first agent comprises: (a) a polymer A composed of one or more organopolysiloxanes containing at least two carbon-carbon double bonds or at least one carbon-carbon triple bond in the molecule; (b) a polymer B composed of one or more organopolysiloxanes containing at least two Si—H units in the molecule; and (c) a silicone having a viscosity of 1.5 mPa.Math.s or less at 25° C., and wherein the second agent comprises a catalyst that promotes cross-linking of the polymer A and the polymer B.

The present disclosure relates to the manufacture of silicon nitride implants with increased surface roughness and porosity.

Embodiments of the invention include silica fiber compositions useful for treatment of animal wounds and tissue, as well as for other applications in industry. The fiber compositions may be formed via electrospinning of a sol gel produced with a silicon alkoxide reagent, such as tetraethyl ortho silicate, alcohol solvent, and an acid catalyst.

The present invention provides moldable, fully scalable cellulose silica-based hydrogels for use as low-cost and safe carriers and aqueous viscosity modifiers in various industrial and medical applications.

An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating bone defects, a method of preparation thereof, and a method of inducing or promoting bone growth by treatment of a bone with an autologous bone graft substitute composition. The composition includes autologous blood; one or more analogs of an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, and combinations thereof; and a compression resistant matrix selected from the group consisting of a bone autograft, bone allograft, hydroxyapatite, tri-calcium phosphate, and combinations thereof. The autologous blood forms a coagulum gel comprising a fibrin-meshwork reinforced with the compression resistant matrix and containing the osteogenic bone morphogenetic protein which is released over a sustained period.

A hydrogel comprising a colloidal suspension of M.sup.I.sub.XM.sup.II.sub.YP.sub.Z two-dimensional nanocrystals in water, wherein M.sup.I is Na.sup.+ and/or Li.sup.+, M.sup.II is Mg.sup.2+ or a mixture of Mg.sup.2+ with one or more Ni.sup.2+, Zn.sup.2+, Cu.sup.2+, Fe.sup.2+ and/or Mn.sup.2+, P is a mixture of dibasic phosphate ions (HPO.sub.4.sup.2−) and tribasic phosphate ions (PO.sub.4.sup.3−). X ranges from about 0.43 to about 0.63, Y ranges from about 0.10 to about 0.18, Z ranges from about 0.29 to about 0.48, X, Y, Z being mole fractions, is provided.

Disclosed are composite materials comprising a porous, carbonated, calcium silicate ceramic having a microstructure comprising interconnected open pores; where the calcium silicate surface defining the pores is partially or completely coated with an amorphous silica layer, and the silica coating comprises an overlayer of calcium carbonate crystals; where the silica coating and calcium carbonate overlayer form a network that interconnects throughout the ceramic microstructure, but do not completely occlude the pores. Also disclosed are methods of forming such composite materials.