A prosthesis, including a prosthetic foot, a prosthetic talocrural joint, a prosthetic ankle pivotally coupled to the prosthetic foot and a four-area bending beam. The four-area bending beam includes a U-shaped or other spring. One end of the spring is mechanically coupled via two of the four areas to the prosthetic foot. The other end of the spring is mechanically coupled via the other two areas to the prosthetic ankle. The spring resiliently resists pivoting of the prosthetic ankle about the prosthetic talocrural joint. The four-area bending beam exhibits an at least approximately constant moment along its length to maximize strain energy density, storing about four times as much elastic energy as a comparable cantilevered beam, thereby providing high stiffness and high range of motion to the ankle. The spring is modular, being easily replaced with another spring exhibiting a different stiffness, ex., to tailor the prosthesis to a user.

A prosthetic venous valve device is disclosed and described, having a valve base including a cylindrical shape with a lumen configured for axial blood flow, the valve base further including an anterograde end and a retrograde end, a pair of flexure pivots coupled to opposite sides of the valve base at the anterograde end, and a pair of leaflets opposingly positioned with respect to one another and each pivotally coupled to one of the pair of flexure pivots, the pair of leaflets being separated from one another in a default open position, wherein the pair of leaflets are structurally configured to pivot from the default open position toward one another to close the prosthetic venous valve to limit retrograde venous blood flow under normal physiologic venous conditions.

A prosthetic venous valve device is disclosed and described, having a valve base including a cylindrical shape with a lumen configured for axial blood flow, the valve base further including an anterograde end and a retrograde end, a pair of flexure pivots coupled to opposite sides of the valve base at the anterograde end, and a pair of leaflets opposingly positioned with respect to one another and each pivotally coupled to one of the pair of flexure pivots, the pair of leaflets being separated from one another in a default open position, wherein the pair of leaflets are structurally configured to pivot from the default open position toward one another to close the prosthetic venous valve to limit retrograde venous blood flow under normal physiologic venous conditions.

The present disclosure relates in part to coating compositions comprising a bactericidal layer further comprising a bactericidal element and a columnar microstructure, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution (i.e. blood or other bodily fluid). The present disclosure further relates to coating compositions stably adhered to an electrode, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution upon application of an electric potential to the underlying electrode without a loss in efficiency of charge transfer.

The present disclosure relates in part to coating compositions comprising a bactericidal layer further comprising a bactericidal element and a columnar microstructure, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution (i.e. blood or other bodily fluid). The present disclosure further relates to coating compositions stably adhered to an electrode, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution upon application of an electric potential to the underlying electrode without a loss in efficiency of charge transfer.

A lithography based method for the manufacture of diamond composite materials in which green bodies are prepared by a layer-by-layer construction with resulting green bodies de-bound and sintered to achieve a dense high hardness material.

A lithography based method for the manufacture of diamond composite materials in which green bodies are prepared by a layer-by-layer construction with resulting green bodies de-bound and sintered to achieve a dense high hardness material.

A method for preparing a conductive biomimetic skin scaffold material with self-repairing function includes the following steps: adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to a homogeneous dispersion of acidified carbon nanotubes, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), and gelatin to cross-link to obtain a conductive composite colloid; and injecting the conductive composite colloid into a mold, aging at −4-4° C. for 12-24 hours, and then soaking in a phosphate-buffered saline (PBS) solution with a pH of 7.0-7.4 for 12-24 hours to obtain the conductive biomimetic skin scaffold material.

A method for preparing a conductive biomimetic skin scaffold material with self-repairing function includes the following steps: adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to a homogeneous dispersion of acidified carbon nanotubes, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), and gelatin to cross-link to obtain a conductive composite colloid; and injecting the conductive composite colloid into a mold, aging at −4-4° C. for 12-24 hours, and then soaking in a phosphate-buffered saline (PBS) solution with a pH of 7.0-7.4 for 12-24 hours to obtain the conductive biomimetic skin scaffold material.

Disclosed are a material with supercapacitance modified surface and a preparation method and application thereof. Specifically, the present disclosure introduces a material having a controllably supercapacitive surface. The surface is chargeable, the full-charged modified surface can interact with bacteria disturbing the electron transfer of respiratory chain of bacteria and inhibiting the growth and reproduction of bacteria in a short-term. The antibacterial rate can be improved by cyclically charging-discharging without losing capacitance, and prevent formation of biofilm of bacteria. The antibacterial system can quantitatively control the antibacterial process without affecting the biocompatibility of the material, and has the advantages of environmental protection and controllability.