An implant and/or an implant component is made available, having a main body which, at least on a surface, contains or consists of an electrically conductive material, and having a layer of calcium hydroxide applied to the electrically conductive material of the main body. The implant or the implant component is characterized in that the layer of calcium hydroxide contains calcium phosphate, specifically in a percentage by weight that is less than the percentage by weight of calcium hydroxide in this layer. A method for making available the implant according to the invention or the implant component according to the invention is also proposed. The implant made available and the implant component made available are characterized in that they have a local and temporary antimicrobial action, prevent formation of antibiotic-resistant microorganisms, act on bone substance in a manner that promotes growth, and produce no adverse side effects in the body.

The present disclosure relates to the manufacture of silicon nitride implants with increased surface roughness and porosity.

The present disclosure relates to the manufacture of silicon nitride implants with increased surface roughness and porosity.

The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient.

The present invention relates to a method for producing hydroxyapatite-bioglass macroporous material, to said materials, and to medical devices thereof.

The method comprises a step of preparation of an aqueous suspension of hydroxyapatite and bioglass with a porogenic agent, and subsequent sintering to achieve a macroporous biomaterial.

The macroporous structure of these materials enhances blood vessels and bone cells migration, allowing bone growth through the interior of the bone substitute, thereby increasing the rate of formation of new bone at the site of implantation. Therefore, these materials are advantageously used to produce medical devices, such as bone grafts that resemble the mineral phase of natural bone showing improved mechanical strength and osteoconductivity.

The biomaterials of the present invention are applicable in the medical area, in particular in bone regeneration and reparation techniques as bone grafts.

The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), a ceramic material and an extracellular matrix. In particular, the biomaterial according the present invention secretes osteoprotegerin (OPG), and comprises insulin-like growth factor (IGF1) and stromal cell-derived factor 1-alpha (SDF-1α). The present invention also relates to methods for producing the biomaterial and uses thereof.

The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), a ceramic material and an extracellular matrix. In particular, the biomaterial according the present invention secretes osteoprotegerin (OPG), and comprises insulin-like growth factor (IGF1) and stromal cell-derived factor 1-alpha (SDF-1α). The present invention also relates to methods for producing the biomaterial and uses thereof.

An implant intended to be at least partially implanted into a bone by means of an implant part having an endosseous surface, wherein said endosseous surface comprises at least one zone having a surface topography exhibiting: an arithmetic mean peak curvature parameter (Spc) less than or equal to 1 μm.sup.1, a density of peaks parameter (Spd) greater than or equal to 0.020 μm.sup.−2.

An implant intended to be at least partially implanted into a bone by means of an implant part having an endosseous surface, wherein said endosseous surface comprises at least one zone having a surface topography exhibiting: an arithmetic mean peak curvature parameter (Spc) less than or equal to 1 μm.sup.1, a density of peaks parameter (Spd) greater than or equal to 0.020 μm.sup.−2.

In one aspect, the disclosure relates to protective, anti-bacterial coatings for medical implants and methods of making the same. Also disclosed herein are methods for improving the anti-bacterial properties of a medical device coated with silicon carbide (SiC) or titanium nitride (TiN). Further disclosed herein are medical devices including an anti-microbial layer prepared by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.