The invention relates to a new type of mesenchymal stem cells (MSC) which co-express at least one mesenchymal marker, preferably at least CD105 and CD34. Also provided are bone-forming cells having an analogous phenotype. The invention also provides the cells and cell populations, as well as further products comprising such and uses thereof in bone therapy.

The invention relates to a new type of mesenchymal stem cells (MSC) which co-express at least one mesenchymal marker, preferably at least CD105 and CD34. Also provided are bone-forming cells having an analogous phenotype. The invention also provides the cells and cell populations, as well as further products comprising such and uses thereof in bone therapy.

A method for producing an implant material by: (A): setting a porous ceramic material having substantially unidirectionally arrayed pores at any depth position inside a container, (B): filling the container with a cell-containing liquid containing at least bone marrow blood and/or peripheral blood, and (C): applying, on the container, a centrifugal force in the direction along the axis of the container.

A method for producing an implant material by: (A): setting a porous ceramic material having substantially unidirectionally arrayed pores at any depth position inside a container, (B): filling the container with a cell-containing liquid containing at least bone marrow blood and/or peripheral blood, and (C): applying, on the container, a centrifugal force in the direction along the axis of the container.

A ceramic composite material and a method for producing same. The ceramic composite material has a ceramic matrix comprising zirconium oxide and at least one secondary phase dispersed therein. The matrix is composed of zirconium oxide as at least 51 vol.-% of composite material, and the secondary phase is in a proportion of 1 to 49 vol.-% of composite material, wherein 90 to 99% of the zirconium oxide is present in the tetragonal phase based on the total zirconium oxide portion. The tetragonal phase of the zirconium oxide is stabilized by at least one member selected from the group consisting of chemical stabilization and mechanical stabilization. The ceramic composite is damage-tolerant.

A ceramic composite material and a method for producing same. The ceramic composite material has a ceramic matrix comprising zirconium oxide and at least one secondary phase dispersed therein. The matrix is composed of zirconium oxide as at least 51 vol.-% of composite material, and the secondary phase is in a proportion of 1 to 49 vol.-% of composite material, wherein 90 to 99% of the zirconium oxide is present in the tetragonal phase based on the total zirconium oxide portion. The tetragonal phase of the zirconium oxide is stabilized by at least one member selected from the group consisting of chemical stabilization and mechanical stabilization. The ceramic composite is damage-tolerant.

A spinal interbody device fabricated of fully resorbable bioactive glass materials is used to maintain the intervertebral spacing in a fusion of adjacent vertebrae. The spinal interbody device can include regions of porous material having various levels of bioactivity so that fusion through ingrowth of bone tissue can be provided while regions of the spinal interbody device can continue to maintain the intervertebral space.

A spinal interbody device fabricated of fully resorbable bioactive glass materials is used to maintain the intervertebral spacing in a fusion of adjacent vertebrae. The spinal interbody device can include regions of porous material having various levels of bioactivity so that fusion through ingrowth of bone tissue can be provided while regions of the spinal interbody device can continue to maintain the intervertebral space.

A method of manufacture of a powder comprising, or consisting essentially of, microspheres, the method comprising: providing a feed powder; and applying at least one spheroidisation flame to the powder. The powder may be suitable for use in medical and/or non-medical applications.

A method of manufacture of a powder comprising, or consisting essentially of, microspheres, the method comprising: providing a feed powder; and applying at least one spheroidisation flame to the powder. The powder may be suitable for use in medical and/or non-medical applications.