A porous hardened material is provided for various medical applications, including strengthening, supporting, moving, reinforcing, separating, isolating, and/or bulking biological substrates. The hardened material is formed from a liquid composition including a fluorinated copolymer and a biocompatible solvent system. The fluorinated copolymer includes a tetrafluoroethylene (TFE) moiety and a vinyl moiety, wherein the vinyl moiety comprises at least one functional group selected from acetate, alcohol, amine, and amide.

A porous hardened material is provided for various medical applications, including strengthening, supporting, moving, reinforcing, separating, isolating, and/or bulking biological substrates. The hardened material is formed from a liquid composition including a fluorinated copolymer and a biocompatible solvent system. The fluorinated copolymer includes a tetrafluoroethylene (TFE) moiety and a vinyl moiety, wherein the vinyl moiety comprises at least one functional group selected from acetate, alcohol, amine, and amide.

An ophthalmological composition includes at least one viscoelastic polymer, wherein the composition comprises at least one thermoresponsive compound that in a predefined wavelength range undergoes a temperature-dependent discontinuous change in at least one physical property from a group color and transmittance. The disclosure further relates to such an ophthalmological composition wherein a temperature-dependent change in the at least one physical property is reversible and/or wherein the temperature-dependent change in the at least one physical property occurs within not more than 10 seconds after a predefined temperature threshold value has been exceeded.

An improved composition for a thermoplastic elastomer that is used in a product that touches the skin. The thermoplastic elastomer contains a styrene block copolymer, a plasticizing oil, and CBD oil. The plasticizing oil and the CBD oil, in combination, comprise at least eighty percent of the thermoplastic elastomer by weight. The plasticizing oil and the CBD oil have the same, or similar, molecular weights. In that manner, the plasticizing oil and the CBD oil can form a homogenous mixture. The CBD oil saturates the thermoplastic elastomer and will slowly bloom out of the thermoplastic elastomer over time. The migration of the CBD oil brings the CBD oil to the exposed surfaces of the thermoplastic elastomer, therein enabling the CBD oil to be absorbed by the skin.

An improved composition for a thermoplastic elastomer that is used in a product that touches the skin. The thermoplastic elastomer contains a styrene block copolymer, a plasticizing oil, and CBD oil. The plasticizing oil and the CBD oil, in combination, comprise at least eighty percent of the thermoplastic elastomer by weight. The plasticizing oil and the CBD oil have the same, or similar, molecular weights. In that manner, the plasticizing oil and the CBD oil can form a homogenous mixture. The CBD oil saturates the thermoplastic elastomer and will slowly bloom out of the thermoplastic elastomer over time. The migration of the CBD oil brings the CBD oil to the exposed surfaces of the thermoplastic elastomer, therein enabling the CBD oil to be absorbed by the skin.

The present application relates to a composition, which comprises: (a) a photopolymerizable substance; (b) a thiol; (c) a photoinitiator; (d) a thermosensitive polymer; and (e) water, and can be used as a bio-ink for preparing a bio-hydrogel for direct-writing 3D printing. The present invention further relates to a method for preparing the composition, and a direct-writing 3D printing method using the composition.

The present application relates to a composition, which comprises: (a) a photopolymerizable substance; (b) a thiol; (c) a photoinitiator; (d) a thermosensitive polymer; and (e) water, and can be used as a bio-ink for preparing a bio-hydrogel for direct-writing 3D printing. The present invention further relates to a method for preparing the composition, and a direct-writing 3D printing method using the composition.

Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.

Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.

The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume V.sub.E; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; iv) the three-dimensionally warped and branched sheet (2) has a volume V.sub.S; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (viii) where the conduits (5) have (a) a mean diameter D.sub.C; and (b) an anisotropicity index of 1.01 to 5.00.