A biocompatible membrane composite including a cell impermeable layer and a mitigation layer is provided. The cell impermeable layer is impervious to vascular ingrowth and prevents cellular contact from the host. Additionally, the mitigation layer includes solid features. In at least one embodiment, mitigation layer has therein bonded solid features. In some embodiments, the cell impermeable layer and the mitigation layer are intimately bonded or otherwise connected to each other to form a composite layer having a tight/open structure. A reinforcing component may optionally be positioned external to or within the biocompatible membrane composite to provide support to and prevent distortion. The biocompatible membrane composite may be used in or to form a device for encapsulating biological entities, including, but not limited to, pancreatic lineage type cells such as pancreatic progenitors.

Materials and methods related to elastomers are disclosed. The disclosed elastomers are useful in implants mimicking soft tissue. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Materials and methods related to elastomers are disclosed. The disclosed elastomers are useful in implants mimicking soft tissue. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The present disclosure provides printable compositions comprising: about 1 weight percent (wt %) to about 40 wt % of one or more hydrophilic monomers; a swelling control agent selected from a hydrophobic monomer, a short chain crosslinker, or a combination thereof; about 0.01 wt % to about 2 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition. The disclosure also includes methods of use and manufacture related to printable compositions.

The present disclosure provides printable compositions comprising: about 1 weight percent (wt %) to about 40 wt % of one or more hydrophilic monomers; a swelling control agent selected from a hydrophobic monomer, a short chain crosslinker, or a combination thereof; about 0.01 wt % to about 2 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition. The disclosure also includes methods of use and manufacture related to printable compositions.

Provided are orthopedic implants and systems and kits containing orthopedic implants that include biodegradable polymer thin films containing an antimicrobial agent, wherein the implants produce an effective zone of inhibition around a periphery of the surface of the implant and do not produce a loss of release torque between interlocking implant components.

Provided are orthopedic implants and systems and kits containing orthopedic implants that include biodegradable polymer thin films containing an antimicrobial agent, wherein the implants produce an effective zone of inhibition around a periphery of the surface of the implant and do not produce a loss of release torque between interlocking implant components.

Composite materials, specifically to materials used in medicine, in particular, in ophthalmology for the manufacturing of optical ophthalmic implants, mainly intraocular lenses (IOL), intended for vision correction after cataract removal. The polymerization rate of the material is controlled in order to eliminate defects in the ophthalmic implant profile, control the geometric dimensions, reduce the finished product glistening while keeping optimal physical and mechanical properties. The material for the manufacturing of ophthalmic implants by photo-polymerization method includes: a) 60-70 wt. % oligomer of urethanedi(meth)acrylate with terminal (meth)acrylate fragments; b) 20-40 wt. % of (meth)acrylate monomers with aromatic substituents in the side chain; c) 5-25 wt. % of (meth)acrylate monomers with aliphatic branched substituents in the side chain; d) at least 0.2 wt. % of a UV-absorbing component; e) 0.1 to 1 wt. % of photopolymerization initiator; and f) 0.005 to 0.5 wt. % of a radical polymerization inhibitor.

Composite materials, specifically to materials used in medicine, in particular, in ophthalmology for the manufacturing of optical ophthalmic implants, mainly intraocular lenses (IOL), intended for vision correction after cataract removal. The polymerization rate of the material is controlled in order to eliminate defects in the ophthalmic implant profile, control the geometric dimensions, reduce the finished product glistening while keeping optimal physical and mechanical properties. The material for the manufacturing of ophthalmic implants by photo-polymerization method includes: a) 60-70 wt. % oligomer of urethanedi(meth)acrylate with terminal (meth)acrylate fragments; b) 20-40 wt. % of (meth)acrylate monomers with aromatic substituents in the side chain; c) 5-25 wt. % of (meth)acrylate monomers with aliphatic branched substituents in the side chain; d) at least 0.2 wt. % of a UV-absorbing component; e) 0.1 to 1 wt. % of photopolymerization initiator; and f) 0.005 to 0.5 wt. % of a radical polymerization inhibitor.

An implantable medical device and methods for making and using the same are provided. In various embodiments, the device comprises a central hub structure in communication with at least one housing or pod capable of containing cells and therapeutic materials. Also provided are membrane structures and methods of forming the same, the membranes comprising a gradient of varying porosity for use with devices of the present disclosure, as well as other uses.