The present disclosure is directed to modified metal materials for implantation and/or bone replacement, and to methods for modifying surface properties of metal substrates for enhancing cellular adhesion (tissue integration) and providing antimicrobial properties. Some embodiments comprise surface coatings for metal implants, such as titanium-based materials, using (1) electrochemical processing and/or oxidation methods, and/or (2) laser processing, in order to enhance bone cell-materials interactions and achieve improved antimicrobial properties. One embodiment comprises the modification of a metal surface by growth of in situ nanotubes via anodization, followed by electrodeposition of silver on the nanotubes. Other embodiments include the use of LENS™ processing to coat a metal surface with calcium-based bioceramic composition layers. These surface treatment methods can be applied as a post-processing operation to metallic implants such as hip, knee and spinal devices as well as screws, pins and plates.

According to the present invention, an implantable device is provided, comprising a substrate on which at least one surface portion is provided. The chemical composition of the surface portion selectively enhances the cell-adhesion to the substrate.

According to the present invention, an implantable device comprising an electrode for carrying an electric signal to or from a biological cell or tissue provided. The electrode material is chosen to exhibit desirable properties in terms of electrical conductivity, biocompatibility and bio-fouling. The invention further provides implantable devices comprising such implantable electrodes.

The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.

The invention relates to an acetabulum (1) for a hip prosthesis, comprising an inner cavity (2) and a rear outer surface (3) facing the bone. In order to be able to implant the acetabulum (1) without using cement, at least some areas of the outer surface (3) are porous and osseointegrative, and the acetabulum (1) is made exclusively of a ceramic material.

In a method and system for producing an implant, the latter is designed with one or more surfaces extending in the longitudinal direction of the implant. Two or three production stages can be used. In one stage, either a topography with a long wave pattern is produced by means of cutting work, or laser bombardment or further cutting work is used to produce a topography with an intermediate-length wave pattern. In addition, an oxidation process or shot-peening or etching is used to produce an outer layer. When using two of said production stages, said cutting work or said laser bombardment or further cutting work is followed by the oxidation process or the shot-peening or etching method. When using all three production stages, cutting work is followed by laser bombardment, or further cutting work, which in turn is followed for example by the oxidation process. The invention also relates to an implant which is produced using the method and is identified, ordered and produced using the system. The invention permits effective treatment of different implant situations.

In a method and system for producing an implant, the latter is designed with one or more surfaces extending in the longitudinal direction of the implant. Two or three production stages can be used. In one stage, either a topography with a long wave pattern is produced by means of cutting work, or laser bombardment or further cutting work is used to produce a topography with an intermediate-length wave pattern. In addition, an oxidation process or shot-peening or etching is used to produce an outer layer. When using two of said production stages, said cutting work or said laser bombardment or further cutting work is followed by the oxidation process or the shot-peening or etching method. When using all three production stages, cutting work is followed by laser bombardment, or further cutting work, which in turn is followed for example by the oxidation process. The invention also relates to an implant which is produced using the method and is identified, ordered and produced using the system. The invention permits effective treatment of different implant situations.

An implantable or insertable medical device can include a silicone substrate and a plasma-enhanced chemical vapor deposition coating on the silicone substrate. The coating may include a silicon-containing compound. A method of forming the coating is also provided.

The invention discloses micron-nano pore gradient oxide ceramic films with biological activity, which are prepared by the following methods: The surface structures are biomedical engineering materials; Inorganic precursor coating solutions or the organic precursor coating solutions are prepared with or without micron and nanopore additives; The surface structures of the substrate are treated in the following steps: (1) The surfaces of the substrate are coated by the inorganic precursor coating solutions or the organic precursor coating solutions with or without micron and nanopore additives; (2) The substrate with coatings are dried, sintered, naturally cooled, and cleaned. (3) The biomedical engineering materials with the micron-nanopore gradient oxide ceramic films, especially biomimetic micro-nanoporous gradient alumina film, yttrium partially stabilized zirconia film, and alumina doped yttrium partially stabilized zirconia films in this invention greatly improve biocompatibility and biological activity.

An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.