The artificial blood vessel comprises a cortex layer, a fibroblast layer, a smooth muscle cell layer, an endothelial cell layer and an inner cavity. According to the artificial blood vessel, the endothelial layer, the smooth muscle cell layer, the fibroblast layer and the cortex layer are orderly arranged in a three-dimensional space by utilizing integrated technologies of plasma spraying, electrospraying, electrospining, intra-mold pouring and 3D printing; anticoagulant activity of the artificial blood vessel is enhanced by adopting an anticoagulation factor; step-by-step induced differentiation of stem cells in the artificial blood vessel is realized by adopting a growth factor controlled release method; and the artificial blood vessel is cultured by a pulsatile reactor, so that the artificial blood vessel structurally and functionally simulates natural animal blood vessels and provides a corresponding substitute for vascular transplantation and repair.

The artificial blood vessel comprises a cortex layer, a fibroblast layer, a smooth muscle cell layer, an endothelial cell layer and an inner cavity. According to the artificial blood vessel, the endothelial layer, the smooth muscle cell layer, the fibroblast layer and the cortex layer are orderly arranged in a three-dimensional space by utilizing integrated technologies of plasma spraying, electrospraying, electrospining, intra-mold pouring and 3D printing; anticoagulant activity of the artificial blood vessel is enhanced by adopting an anticoagulation factor; step-by-step induced differentiation of stem cells in the artificial blood vessel is realized by adopting a growth factor controlled release method; and the artificial blood vessel is cultured by a pulsatile reactor, so that the artificial blood vessel structurally and functionally simulates natural animal blood vessels and provides a corresponding substitute for vascular transplantation and repair.

A method for cartilage tissue engineering including fabricating a nanocomposite, injecting the nanocomposite into a defect site of cartilage, and forming a hydrogel in the defect site of the cartilage using a sol-gel transition responsive to increasing temperature of the nanocomposite from room temperature to 37° C. Fabricating a nanocomposite includes forming an activated copolymer by functionalizing a copolymer, forming a conjugated copolymer by grafting the activated copolymer to a polysaccharide, forming a protein-conjugated copolymer by crosslinking a protein with the conjugated copolymer, forming the nanocomposite by adding a plurality of nanoparticles to the protein-conjugated copolymer.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

The invention generally relates to a method of regenerating a nerve fiber in a damaged neural tissue of a patient, the method comprising the steps of: administering an aqueous formulation comprising superparamagnetic particles to the damaged neural tissue in the patient; applying a magnetic field in an orientation which is parallel to the nerve fiber; using the magnetic field for aligning the superparamagnetic particles; forming one or more aligned chains of the superparamagnetic particles in the magnetic field as a scaffold to guide directional growth of regenerating nerve cells; and reconnecting damaged nerve ends in the damaged neural tissue of the patient.

The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.

The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.

Disclosed herein are a cocoon-based, vascular patch and a method for manufacturing the same. The cocoon-based, vascular patch is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a predetermined thickness. The cocoon-based vascular patch can be relatively simply manufactured in a more cost efficient manner than conventional vascular patches, and has excellent cell growth potential and biocompatibility.

Disclosed herein are a cocoon-based, vascular patch and a method for manufacturing the same. The cocoon-based, vascular patch is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a predetermined thickness. The cocoon-based vascular patch can be relatively simply manufactured in a more cost efficient manner than conventional vascular patches, and has excellent cell growth potential and biocompatibility.

The present application is directed to the field of scaffolds for tissue engineering. The scaffolds are typically comprised of nanofibers and are optionally biomineralized. The present application provides a process for forming nanofibrous materials via electrospinning and for biomineralizing such materials. The scaffolds of the present application can be biomineralized and contain a plurality of cells either on or within the scaffold, resulting in synthetic, bioresorbable scaffolds that can be used in various biomedical applications, such as for bone regeneration.