The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. More particularly, the invention provides for compositions and methods for preparing silk fibroin biocompatible polyurethane membranes using a solvent, which have improved biodegradation, mechanical and vibroacoustic properties.

The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. More particularly, the invention provides for compositions and methods for preparing silk fibroin biocompatible polyurethane membranes using a solvent, which have improved biodegradation, mechanical and vibroacoustic properties.

A three-dimensional, biocompatible scaffold precursor composition for room-temperature printing a bio-compatible polymer/hydroxyapatite composite scaffold includes a room-temperature slurry, comprising a mixture of a sold phase that includes a mixture of tetracalcium phosphate (TTCP; Ca.sub.4(PO.sub.4).sub.2O) and dicalcium phosphate anhydrous (DCPA; CaHPO.sub.4), and a liquid phase that includes a polymer in a solvent. The solvent may be Ethanol (EtOH) or Tetrahydrofuran (THF), and the polymer may be polyvinyl butyral (PVB), polycaprolactone (PCL), or poly lactic-co-glycolic acid (PLGA). The slurry is printed at room temperature in aqueous phosphate (NaH.sub.2PO.sub.4) bath, which works as hardening accelerator, forming the polymer/hydroxyapatite composite scaffold.

The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.

The present disclosure relates to the technical field of medicines, and in particular, to a composite scaffold material, a preparation method therefor and use thereof. The present disclosure provides a composite scaffold material, including a charged fiber framework material. The fiber framework material is coated with positively charged biocompatible materials and negatively charged biocompatible materials alternately, by means of electrostatic attraction. The composite scaffold material of the present disclosure overcomes the defects of traditional scaffold materials, such as poor hydrophilicity, biocompatibility, histiocyte adhesion ability, and biological induction activity. The composite scaffold material has better applicability when used for tissue adhesion, closure, leaking stoppage, hemostasis, isolation, repair, and adhesion prevention, and can also be used for preparing a drug carrier (e.g., sustained release carrier) and a tissue engineering scaffold material. Therefore the composite scaffold material has a wide range of industrial uses.

The present disclosure relates to the technical field of medicines, and in particular, to a composite scaffold material, a preparation method therefor and use thereof. The present disclosure provides a composite scaffold material, including a charged fiber framework material. The fiber framework material is coated with positively charged biocompatible materials and negatively charged biocompatible materials alternately, by means of electrostatic attraction. The composite scaffold material of the present disclosure overcomes the defects of traditional scaffold materials, such as poor hydrophilicity, biocompatibility, histiocyte adhesion ability, and biological induction activity. The composite scaffold material has better applicability when used for tissue adhesion, closure, leaking stoppage, hemostasis, isolation, repair, and adhesion prevention, and can also be used for preparing a drug carrier (e.g., sustained release carrier) and a tissue engineering scaffold material. Therefore the composite scaffold material has a wide range of industrial uses.

Reinforced biocomposite materials. According to at least some embodiments, medical implants are provided that incorporate novel structures, alignments, orientations and forms comprised of such reinforced bioabsorbable materials, as well as methods of treatment thereof.

An intravascular cell therapy device comprises a scaffold (2, 12) that is radially adjustable between a contracted orientation suitable for transluminal delivery to a vascular locus and an expanded orientation, and a biodegradable matrix provided on at least a portion of the scaffold that is suitable for seeding with cells and degrades in a vascular environment. The scaffold is configured to have a distal piercing tip (5) when in a deployed orientation. The scaffold comprises a plurality of sidewall panels (3, 13, 14) arranged around a longitudinal axis of the scaffold, and adjustable couplings (4) between the panels configured for adjustment between an expanded configuration and a contracted orientation, and in which each sidewall panel comprises a matrix suitable for seeding with cells.

An intravascular cell therapy device comprises a scaffold (2, 12) that is radially adjustable between a contracted orientation suitable for transluminal delivery to a vascular locus and an expanded orientation, and a biodegradable matrix provided on at least a portion of the scaffold that is suitable for seeding with cells and degrades in a vascular environment. The scaffold is configured to have a distal piercing tip (5) when in a deployed orientation. The scaffold comprises a plurality of sidewall panels (3, 13, 14) arranged around a longitudinal axis of the scaffold, and adjustable couplings (4) between the panels configured for adjustment between an expanded configuration and a contracted orientation, and in which each sidewall panel comprises a matrix suitable for seeding with cells.

Provided herein is technology relating to materials having microscale and/or nanoscale features and particularly, but not exclusively, to porous materials comprising microscale features, methods for producing porous materials comprising microscale features, drug delivery vehicles, and related kits, systems, and uses.