A textile graft includes a tubular wall disposed between a first open end and an opposed second open end and having an inner surface and an opposed outer surface. The tubular wall includes a textile construction of one or more filaments or yarns, the textile construction by itself being permeable to liquid. A portion of the inner surface of the tubular wall includes a coating of a substantially water-soluble material thereon. The outer surface includes a coating of a substantially water-insoluble elastomeric sealant disposed thereon. The tubular wall having the coating of the substantially water-insoluble elastomeric sealant is, after curing thereof, substantially impermeable to liquid.

Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi-directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.

A textile graft includes a tubular wall disposed between a first open end and an opposed second open end and having an inner surface and an opposed outer surface. The tubular wall includes a textile construction of one or more filaments or yarns, the textile construction by itself being permeable to liquid. A portion of the inner surface of the tubular wall includes a coating of a substantially water-soluble material thereon. The outer surface includes a coating of a substantially water-insoluble elastomeric sealant disposed thereon. The tubular wall having the coating of the substantially water-insoluble elastomeric sealant is, after curing thereof, substantially impermeable to liquid.

A tissue-filling composition comprises an injectable material having the properties of a Bingham plastic. The tissue-filling composition is a solid which partially liquefies as it is injected through a needle or cannula into solid tissue. The tissue-filling composition may be a poly(vinyl alcohol) produced from an aqueous solution which is subjected to a single freeze-thaw cycle under conditions which cause the poly(vinyl alcohol) to have the properties of a Bingham plastic.

The invention relates to a scaffold material composition for forming a solid tissue scaffold, the composition comprising a plurality of hollow polymer pellets, each pellet comprising an open hollow extending through the pellet, and wherein the plurality of hollow polymer pellets are capable of interlinking and setting into a solid scaffold. The invention further relates to associated compositions, uses, method of treatment and kits associated with such material.

The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.

A method of manufacturing a tubular graft may include the steps of: providing a textile including a tubular wall disposed between a first open end and an opposed second open end, an inner surface and an opposed outer surface defining an interior wall portion therein between, the tubular wall including a textile construction of one or more filaments or yarns, the textile construction by itself being permeable to liquid; applying a substantially water-soluble material to at least a portion of the tubular wall; and applying a substantially water-insoluble sealant to at least a part of the outer surface of the tubular wall, the substantially water-insoluble sealant being configured to mitigate movement of fluid through the wall of the conduit; where the water-soluble material is configured to mitigate penetration of the sealant to the inner surface of the conduit.

A substrate for transplanting a skin micrograft. The substrate may be configured to receive the tissue micrograft and be positioned at a recipient site. The substrate may have a first surface and a second surface, and may include a bioresorbable material and an adhesive. The bioresorbable material may include oxidized regenerated cellulose (ORC), for example, from about 40% to about 50% by weight of the substrate. The bioresorbable material may include collagen, for example, from about 50% to about 60% by weight of the substrate. The adhesive may include a sugar, for example, glucose from about 8% to about 16% by weight of the substrate. The bioresorbable material may include a plasticizer, for example, glycerol.

The present invention relates to polyvinvyl chloride (PVC) admixtures with plasticizers and surface modifying macromolecules. In accordance with embodiments, articles formed from the compositions disclosed herein may reduce leaching of plasticizers.

The described invention provides soft tissue grafts, hard tissue grafts, and composite soft/hard tissue grafts and methods of producing such grafts. The grafts comprise a three-dimensional carrier matrix, a growth factor composition comprising an autologous platelet-rich fibrin and a cell culture composition comprising a culture medium, a population of cells suspended in the culture medium, and cells impregnated on or in a surface of osteoconductive particles.