The present invention relates to a parenteral composition for maintaining the efficacy of a filler for a long time, containing a collagen hydrolysate as an active ingredient. The composition, according to the present invention, can maintain the efficacy of a hyaluronic acid filler for a longer time, thereby enabling the effect thereof to be maintained irrespective of a smaller frequency of filler operations, and thus there is an advantage of also reducing skin irritation. In addition, there is an advantage of enabling an immediate effect since an administration method is simple as a parenteral administration and enables direct penetration into the skin.

A method for preparing a highly elastic biodegradable three-dimensional structure and a highly elastic biodegradable three-dimensional structure obtained thereby, particularly, a method for preparing a three-dimensional structure maintains mechanical properties even after three-dimensional printing, by adding a biocompatible heat stabilizer to poly(L-lactide-co--caprolactone) and application of the three-dimensional structure to a scaffold for tissue engineering.

The three-dimensional lattice structures disclosed herein have applications including use in medical implants. Some examples of the lattice structure are structural in that they can be used to provide structural support or mechanical spacing. In some examples, the lattice can be configured as a scaffold to support bone or tissue growth. Some examples can use a repeating modified rhombic dodecahedron or radial dodeca-rhombus unit cell. The lattice structures are also capable of providing a lattice structure with anisotropic properties to better suit the lattice for its intended purpose.

The present invention is directed to injectable acid soluble collagen compositions comprising a neutralized solution of an acid soluble collagen, EDTA and preferably a polyol, wherein the composition is injectable at physiological pH and the acid soluble collagen polymerizes upon exposure to tissue. The invention is suitable for use in soft tissue augmentation, promoting soft tissue regeneration and coating medical implants and devices.

Various embodiments disclosed relate to melt-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of melt-stabilizing a material including UHMWPE. The method includes obtaining or providing a solid material including UHMWPE including a first concentration of free-radicals. The method includes coating at least part of the solid material with a liquid composition including at least one antioxidant, to provide a coated solid material. The method includes heating the coated solid material in an environment including oxygen, the heating being sufficient to melt at least part of the UHMWPE, to provide a heated material. The method also includes solidifying the heated material, to provide a melt-stabilized material including UHMWPE including a second concentration of free-radicals, wherein the second concentration of free-radicals is less than the first concentration of free-radicals.

Pyruvate may be used to stabilize hyaluronic acid compositions. For example, these compositions may have improved heat and/or storage stability.

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.

A biological composition intermixed with a polyampholyte protectant for direct implantation has a mixture of biologic material and a volume of polyampholyte protectant. The mixture of biologic material has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components, or whole cells or combinations of the non-whole cellular components and whole cells, wherein the mixture is compatible with biologic function. The volume of polyampholyte protectant is intermixed with the mixture of biologic material, wherein the polyampholyte protectant is a liquid of a polyamine polymer compound of carboxylated poly-lysine and wherein the polyampholyte protectant forms a three-dimensional bonding shroud externally enveloping each of the non-whole cellular components, if any, and each of the whole cells, if any, of the mixture of biologic material.

Disclosed are an absorbable iron-based alloy implanted medical device (1) and preparation method thereof. The device (1) comprises an iron-based alloy base (11), a degradable polymer (13) arranged on the surface of the iron-based alloy base, and an alkaline protector (12) arranged on the surface of the iron-based alloy base. The alkaline protector (12) contains at least one alkaline substance capable of neutralizing the acidic substance produced by the polymer at the early stage after the device is implanted to delay the corrosion of the iron-based alloy base (1) in the early stage of implantation, hence the iron-based alloy base (12) would not substantially corrode or would corrode slowly, clinically satisfying the mechanical properties and requirements of the device (1) in the early stage of implantation; and in the meantime, after the neutralization and consumption of the alkaline protector (12) exposes the base (11), the base (11) can still accelerate the corrosion speed thereof in the acidic environment formed by the polymer (13), so as to clinically satisfy the requirement of the corrosion cycle of the device (1) at the same time.