A delivery device or patch is disclosed that includes a detachable hybrid microneedle depot (d-HMND) for cell delivery. The system includes, in one embodiment, an array of microneedles formed from an outer PLGA shell and an internal gelatin methacryloyl (GelMA)-mesenchymal stem cells (MSC) mixture (GMM). The array of microneedles project from a base substrate layer that may be flexible. The therapeutic device may be applied to a tissue site of interest and the base substrate layer is removed leaving the hybrid microneedles in the tissue at the site of application to deliver MSCs. Other stem/therapeutic cells may also be delivered with the hybrid microneedles.

The disclosure relates to a spacer using a hydrogel for treatment that aids in growth or bonding of living tissues after surgery or treatment of joints, muscles, or ligaments. The spacer includes a support sheet formed of a biodegradable hydrogel material having a water-soluble polymer network structure, and a pouch formed of a biodegradable material, as a sealing bag-shaped member surrounding the support sheet, and the support sheet is formed to dissolve in a body fluid faster than the pouch. Therefore, the spacer and a method of manufacturing the spacer according to the disclosure may eliminate cost and stress because there is no need for a subsequent removal operation, while stabilizing a surgical site and reducing pain, and particularly, adjust a drug delivery rate adaptively according to different recovery rates or tissue regeneration rates for different ages of patients.

The disclosure relates to a spacer using a hydrogel for treatment that aids in growth or bonding of living tissues after surgery or treatment of joints, muscles, or ligaments. The spacer includes a support sheet formed of a biodegradable hydrogel material having a water-soluble polymer network structure, and a pouch formed of a biodegradable material, as a sealing bag-shaped member surrounding the support sheet, and the support sheet is formed to dissolve in a body fluid faster than the pouch. Therefore, the spacer and a method of manufacturing the spacer according to the disclosure may eliminate cost and stress because there is no need for a subsequent removal operation, while stabilizing a surgical site and reducing pain, and particularly, adjust a drug delivery rate adaptively according to different recovery rates or tissue regeneration rates for different ages of patients.

A composition useful in forming a structure in the form of a substantially interconnected vascular network. The composition includes a powder including a carbohydrate powder and an anti-caking agent, where the powder: has a granular form, and has a specific energy of less than 6 millijoules per milliliter (mJ/mL).

An injectable medical composition includes an acrylate and a solvent. The composition has a first viscosity at temperatures below body temperature and a second viscosity at body temperature. The first viscosity is lower than the second viscosity.

An injectable medical composition includes an acrylate and a solvent. The composition has a first viscosity at temperatures below body temperature and a second viscosity at body temperature. The first viscosity is lower than the second viscosity.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

The invention provides a highly versatile system to promote vascularization in ischemic tissue. The system is composed of a fully defined, customizable hydrogel loaded with a potent cocktail of proangiogenic growth factors. The hydrogel's mechanical, degradation, and factor release behavior can be tailored to the specifications of any given target tissue or ischemic disease state. The growth factor cocktail can be optimized for maximal vessel density or size to meet the perfusion specifications required by the tissue. The embodiments of the disclosure concern methods and compositions of the system, with examples of preparation for both injectable and implantable delivery modes.