A shrouded screw apparatus includes an outer tube, a telescoping inner tube, an auger bit, and an anti-rotation pin. The outer tube has a first sidewall defining a first interior chamber. The first sidewall has an opening defined therethrough. The inner tube is positioned in the first interior chamber. The inner tube has a second sidewall defining a second interior chamber. The second sidewall has a longitudinal groove defined therein. The inner tube is configured to extend from and retract within the first interior chamber of the outer tube. The auger bit is positioned in the second interior chamber and is rotatably coupled to the inner tube. The anti-rotation pin is coupled to the first sidewall of the outer tube and extends inwardly into the first interior chamber. The pin engages the longitudinal groove of the inner tube.

A shrouded screw apparatus includes an outer tube, a telescoping inner tube, an auger bit, and an anti-rotation pin. The outer tube has a first sidewall defining a first interior chamber. The first sidewall has an opening defined therethrough. The inner tube is positioned in the first interior chamber. The inner tube has a second sidewall defining a second interior chamber. The second sidewall has a longitudinal groove defined therein. The inner tube is configured to extend from and retract within the first interior chamber of the outer tube. The auger bit is positioned in the second interior chamber and is rotatably coupled to the inner tube. The anti-rotation pin is coupled to the first sidewall of the outer tube and extends inwardly into the first interior chamber. The pin engages the longitudinal groove of the inner tube.

The present invention relates to methods for treating or preventing pulmonary hypertension, reducing mortality in a subject experiencing pulmonary hypertension, or inhibiting ADP-mediated vasoconstriction of pulmonary arteries in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising a reversible P2Y.sub.12 receptor antagonist. Also provided are related medicaments, pharmaceutical compositions, and methods for preparing the medicaments.

The present invention relates to methods for treating or preventing pulmonary hypertension, reducing mortality in a subject experiencing pulmonary hypertension, or inhibiting ADP-mediated vasoconstriction of pulmonary arteries in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising a reversible P2Y.sub.12 receptor antagonist. Also provided are related medicaments, pharmaceutical compositions, and methods for preparing the medicaments.

Provided is an adjustable split thrust ring and a drilling system including the same. The adjustable split thrust ring, in one embodiment, includes a downhole split ring including two or more separate downhole pieces, the two or more separate downhole pieces fitting together to form a substantially circular downhole shoulder surrounding a substantially circular driveshaft. The adjustable split thrust ring further includes an uphole split ring positionable proximate the downhole split ring and including two or more separate uphole pieces, the two or more separate uphole pieces fitting together to form a substantially circular uphole shoulder surrounding the substantially circular driveshaft. In this embodiment, the substantially circular downhole shoulder and the substantially circular uphole shoulder are movable relative to one another to adjust to fit a groove in a driveshaft that they are configured to sit.

Provided is an adjustable split thrust ring and a drilling system including the same. The adjustable split thrust ring, in one embodiment, includes a downhole split ring including two or more separate downhole pieces, the two or more separate downhole pieces fitting together to form a substantially circular downhole shoulder surrounding a substantially circular driveshaft. The adjustable split thrust ring further includes an uphole split ring positionable proximate the downhole split ring and including two or more separate uphole pieces, the two or more separate uphole pieces fitting together to form a substantially circular uphole shoulder surrounding the substantially circular driveshaft. In this embodiment, the substantially circular downhole shoulder and the substantially circular uphole shoulder are movable relative to one another to adjust to fit a groove in a driveshaft that they are configured to sit.

Provided is an adjustable split thrust ring and a drilling system including the same. The adjustable split thrust ring, in one embodiment, includes a downhole split ring including two or more separate downhole pieces, the two or more separate downhole pieces fitting together to form a substantially circular downhole shoulder. The adjustable split thrust ring further includes an uphole split ring positionable proximate the downhole split ring and including two or more separate uphole pieces, the two or more separate uphole pieces fitting together to form a substantially circular uphole shoulder. In this embodiment, the substantially circular downhole shoulder and the substantially circular uphole shoulder are movable relative to one another to adjust to fit a groove in a driveshaft that they are configured to sit.

Provided is an adjustable split thrust ring and a drilling system including the same. The adjustable split thrust ring, in one embodiment, includes a downhole split ring including two or more separate downhole pieces, the two or more separate downhole pieces fitting together to form a substantially circular downhole shoulder. The adjustable split thrust ring further includes an uphole split ring positionable proximate the downhole split ring and including two or more separate uphole pieces, the two or more separate uphole pieces fitting together to form a substantially circular uphole shoulder. In this embodiment, the substantially circular downhole shoulder and the substantially circular uphole shoulder are movable relative to one another to adjust to fit a groove in a driveshaft that they are configured to sit.

A wellbore roller-reamer comprises a mandrel rotatable about a mandrel axis, and a first roller mounted around the mandrel and having an outer reaming surface for engaging a wall of a wellbore. The first roller is rotatable relative to the mandrel about a first roller axis which is offset from the mandrel axis such that, during use, rotation of the mandrel with the outer reaming surface engaged with a wall of the wellbore causes the first roller to be driven to rotate relative to the mandrel and ream the wall of the wellbore.

A wellbore roller-reamer comprises a mandrel rotatable about a mandrel axis, and a first roller mounted around the mandrel and having an outer reaming surface for engaging a wall of a wellbore. The first roller is rotatable relative to the mandrel about a first roller axis which is offset from the mandrel axis such that, during use, rotation of the mandrel with the outer reaming surface engaged with a wall of the wellbore causes the first roller to be driven to rotate relative to the mandrel and ream the wall of the wellbore.